The purpose of this study was to investigate the changes in mitochondria in porcine MII-
stage oocytes after open pulled straw (OPS) vitrification and to determine their roles in …

BACKGROUND Insulin resistance (IR) and hyperinsulinemia compromise fertility in females
and are well-recognized characteristics of anovulatory women with polycystic ovary …

Ageing is associated with structural and functional alterations in all organs of the human
body. The ageing of gonads represents in this respect a special case, because these organs …

The primary aim of the present study was to examine the effect of maternal age (in months)
on mitochondrial DNA copy number (Mt number), ATP content and IVF outcome of bovine …

Maternal obese environment has been reported to induce oxidative stress and meiotic
defects in oocytes, however the underlying molecular mechanism remains unclear. Here …

BACKGROUND The use of nuclear transfer (NT) has been proposed as a novel
reproductive treatment to overcome the transmission of maternally-inherited mitochondrial …

The requirement for oxidative metabolism of pyruvate during oogenesis in vivo was
evaluated by inactivating Pdha1, a gene encoding an enzymatic subunit of pyruvate …

Mitochondria affect numerous aspects of mammalian reproduction. We investigated whether
the decrease in oocyte quality associated with aging is related to altered mitochondria …

The reproductive system of human female exhibits a much faster rate of aging than other
body systems. Ovarian aging is thought to be dominated by a gradual decreasing numbers …

In their midthirties, women experience a decline in fertility, coupled to a pronounced
increase in the risk of aneuploidy, miscarriage, and birth defects. Although the aetiology of …