Advances in chemical and biological methods to identify microorganisms—from past to present

R Franco-Duarte, L Černáková, S Kadam, K S. Kaushik… - Microorganisms, 2019 - mdpi.com
Fast detection and identification of microorganisms is a challenging and significant feature
from industry to medicine. Standard approaches are known to be very time-consuming and …

Metabolomics in the context of plant natural products research: From sample preparation to metabolite analysis

MA Salem, L Perez de Souza, A Serag, AR Fernie… - Metabolites, 2020 - mdpi.com
Plant-derived natural products have long been considered a valuable source of lead
compounds for drug development. Natural extracts are usually composed of hundreds to …

Metabolomics 20 years on: what have we learned and what hurdles remain?

S Alseekh, AR Fernie - The Plant Journal, 2018 - Wiley Online Library
The term metabolome was coined in 1998, by analogy to genome, transcriptome and
proteome. The first research papers using the terms metabolomics, metabonomics …

The use of metabolomics to dissect plant responses to abiotic stresses

T Obata, AR Fernie - Cellular and Molecular Life Sciences, 2012 - Springer
Plant metabolism is perturbed by various abiotic stresses. As such the metabolic network of
plants must be reconfigured under stress conditions in order to allow both the maintenance …

Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy

WB Dunn, DI Broadhurst, HJ Atherton… - Chemical society …, 2011 - pubs.rsc.org
The study of biological systems in a holistic manner (systems biology) is increasingly being
viewed as a necessity to provide qualitative and quantitative descriptions of the emergent …

Integrated, nontargeted ultrahigh performance liquid chromatography/electrospray ionization tandem mass spectrometry platform for the identification and relative …

AM Evans, CD DeHaven, T Barrett, M Mitchell… - Analytical …, 2009 - ACS Publications
To address the challenges associated with metabolomics analyses, such as identification of
chemical structures and elimination of experimental artifacts, we developed a platform that …

Mass appeal: metabolite identification in mass spectrometry-focused untargeted metabolomics

WB Dunn, A Erban, RJM Weber, DJ Creek, M Brown… - Metabolomics, 2013 - Springer
Metabolomics has advanced significantly in the past 10 years with important developments
related to hardware, software and methodologies and an increasing complexity of …

Chemometric methods in data processing of mass spectrometry-based metabolomics: A review

L Yi, N Dong, Y Yun, B Deng, D Ren, S Liu… - Analytica chimica acta, 2016 - Elsevier
This review focuses on recent and potential advances in chemometric methods in relation to
data processing in metabolomics, especially for data generated from mass spectrometric …

Mass spectrometry‐based plant metabolomics: Metabolite responses to abiotic stress

TF Jorge, JA Rodrigues, C Caldana… - Mass spectrometry …, 2016 - Wiley Online Library
Metabolomics is one omics approach that can be used to acquire comprehensive
information on the composition of a metabolite pool to provide a functional screen of the …

JUNGBRUNNEN1, a Reactive Oxygen Species–Responsive NAC Transcription Factor, Regulates Longevity in Arabidopsis

A Wu, AD Allu, P Garapati, H Siddiqui, H Dortay… - The Plant …, 2012 - academic.oup.com
The transition from juvenility through maturation to senescence is a complex process that
involves the regulation of longevity. Here, we identify JUNGBRUNNEN1 (JUB1), a hydrogen …