Chlamydia trachomatis: Protective Adaptive Responses and Prospects for a Vaccine

TB Poston, T Darville - Biology of Chlamydia, 2018 - Springer
Chlamydia trachomatis is the most common cause of sexually transmitted bacterial infection
globally. These infections translate to a significant public health burden, particularly …

[HTML][HTML] Chlamydial plasmid-encoded virulence factor Pgp3 interacts with human cathelicidin peptide LL-37 to modulate immune response

S Hou, X Sun, X Dong, H Lin, L Tang, M Xue… - Microbes and …, 2019 - Elsevier
We have previously reported that Chlamydia trachomatis plasmid-encoded Pgp3 is able to
neutralize anti-chlamydial activity of human cathelicidin peptide LL-37 by binding to and …

Protective immunity against mouse upper genital tract pathology correlates with high IFNγ but low IL-17 T cell and anti-secretion protein antibody responses induced …

C Lu, H Zeng, Z Li, L Lei, IT Yeh, Y Wu, G Zhong - Vaccine, 2012 - Elsevier
To search for optimal immunization conditions for inducing protective immunity against
upper genital tract pathologies caused by chlamydial intravaginal infection, we compared …

[HTML][HTML] Structure of the Chlamydia trachomatis immunodominant antigen Pgp3

A Galaleldeen, AB Taylor, D Chen… - Journal of Biological …, 2013 - ASBMB
Chlamydia trachomatis infection is the most common sexually transmitted bacterial disease.
Left untreated, it can lead to ectopic pregnancy, pelvic inflammatory disease, and infertility …

The Plasmid-Encoded pGP3 Promotes Chlamydia Evasion of Acidic Barriers in Both Stomach and Vagina

T Zhang, Z Huo, J Ma, C He, G Zhong - Infection and immunity, 2019 - Am Soc Microbiol
Although Chlamydia trachomatis is a human genital tract pathogen, chlamydial organisms
have frequently been detected in both vaginal and rectal swab samples of animals and …

Comparison of the nine polymorphic membrane proteins of Chlamydia trachomatis for their ability to induce protective immune responses in mice against a C …

S Pal, A Favaroni, DF Tifrea, PT Hanisch, SET Luczak… - Vaccine, 2017 - Elsevier
Objectives To test vaccines, formulated with novel antigens, to protect mice against
Chlamydia infections. Methods To determine the ability of polymorphic membrane proteins …

Subunit vaccines for the prevention of mucosal infection with Chlamydia trachomatis

H Yu, KP Karunakaran, X Jiang… - Expert review of …, 2016 - Taylor & Francis
Chlamydia trachomatis is the most common preventable cause of tubal infertility in women.
In high-income countries, despite public health control efforts, C. trachomatis case rates …

[HTML][HTML] Inadequate reference datasets biased toward short non-epitopes confound B-cell epitope prediction

KS Rahman, EU Chowdhury, K Sachse… - Journal of Biological …, 2016 - ASBMB
X-ray crystallography has shown that an antibody paratope typically binds 15–22 amino
acids (aa) of an epitope, of which 2–5 randomly distributed amino acids contribute most of …

[HTML][HTML] Comparison of platforms for testing antibody responses against the Chlamydia trachomatis antigen Pgp3

S Gwyn, G Cooley, B Goodhew, S Kohlhoff… - The American Journal …, 2017 - ncbi.nlm.nih.gov
Antibody responses to Chlamydia trachomatis (CT) antigens may be useful tools for
surveillance of trachoma by estimating cumulative prevalence of infection within a …

[HTML][HTML] Immunogenicity and Protective Capacity of a Virus-like Particle Vaccine against Chlamydia trachomatis Type 3 Secretion System Tip Protein, CT584

E Webster, KW Seiger, SB Core, AL Collar… - Vaccines, 2022 - mdpi.com
An effective vaccine against Chlamydia trachomatis is urgently needed as infection rates
continue to rise and C. trachomatis causes reproductive morbidity. An obligate intracellular …