Cardiovascular diseases (CVDs) are a significant health burden with an ever-increasing
prevalence. They remain the leading causes of morbidity and mortality worldwide. The use …

Abstract Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological
functions and pathological significances and play an important role in health and disease. In …

The myeloid-derived suppressor cell (MDSC) is the 'queen bee'of the tumor
microenvironment. MDSCs protect the cancer from the patient's immune system, make the …

Aims Sodium-glucose co-transporter 2 (SGLT2) were originally developed as kidney-
targeting anti-diabetic drugs. However, due to their beneficial cardiac off-target effects (as …

Cerebral small vessel disease (cSVD) is the most common cause of vascular cognitive
impairment and affects all levels of the brain's vasculature. Features include diverse …

Aging is a key aspect of neoplasia at the level of cells, individuals and populations.
Unrestrained expression and production of inflammatory mediators is a key feature of aging …

Atherosclerosis is a well-known global health problem. Despite the high prevalence of the
disease, numerous aspects of pathogenesis remain unclear. Subsequently, there are still no …

Background Following an acute myocardial infarction (MI), patients with persistently
elevated biomarkers of inflammation, in particular C-reactive protein (CRP), are at …

Overwhelming epidemiological evidence demonstrate that cardiovascular disease and
cancer represent major health burdens in the United States, and they are the leading causes …

Inflammation is a well‐known feature of heart failure. Studies have shown that while some
inflammation is required for repair during injury and is protective, prolonged inflammation …