Environmental factors are known to interact with the genome by altering epigenetic
mechanisms regulating gene expression and contributing to the pathogenesis of psychiatric …

The risk of depression is influenced by both genetic and environmental factors. It has been
suggested that epigenetic mechanisms may mediate the risk of depression following …

Major depressive disorder (MDD) is a prevalent and devastating mental illness. To date, the
diagnosis of MDD is largely dependent on clinical interviews and questionnaires and still …

With this letter we would like to refer to the review on the topic of neuroplasticity,
hippocampus and depression, in which, however, electroconvulsive therapy (ECT) was …

Electroconvulsive therapy (ECT) appears to be the most effective treatment for severe
depression. However, its mechanisms of action are incompletely understood. Evidence …

Introduction Precision medicine in psychiatry is still in its infancy. To establish patient-
tailored treatment, adequate indicators predicting treatment response are required …

Background: Stressful events increase the risk for treatment-resistant depression (TRD), and
trauma-focused psychotherapy can be useful for TRD patients exposed to early life stress …

Major depressive disorder (MDD) is a recurring affective disorder that is two times more
prevalent in females than males. Evidence supports immune system dysfunction as a major …

Major depressive disorder (MDD) is a debilitating and prevalent mental disorder with a high
disease burden. Despite a wide array of different treatment options, many patients do not …

Electroconvulsive therapy (ECT) is one of the most effective strategies for treating resistant
major depression. Although the mechanism of action is not fully understood and studies are …