Paraquat poisonings: mechanisms of lung toxicity, clinical features, and treatment

RJ Dinis-Oliveira, JA Duarte… - Critical reviews in …, 2008 - Taylor & Francis
Paraquat dichloride (methyl viologen; PQ) is an effective and widely used herbicide that has
a proven safety record when appropriately applied to eliminate weeds. However, over the …

Different effects of growth factors on proliferation and matrix production of normal and fibrotic human lung fibroblasts

M Hetzel, M Bachem, D Anders, G Trischler… - Lung, 2005 - Springer
Objectives and methods: In idiopathic pulmonary fibrosis (IPF), proliferation of fibroblasts
and increased matrix deposition result in pulmonary damage and respiratory insufficiency …

Idiopathic pulmonary fibrosis may be a disease of recurrent, tractional injury to the periphery of the aging lung: a unifying hypothesis regarding etiology and …

KO Leslie - Archives of pathology & laboratory medicine, 2012 - meridian.allenpress.com
Context.—Idiopathic pulmonary fibrosis is a progressive, fatal lung disease occurring in
older individuals. Despite 50 years of accrued data about the disease, little progress has …

Epigallocatechin-3-gallate augments antioxidant activities and inhibits inflammation during bleomycin-induced experimental pulmonary fibrosis through Nrf2–Keap1 …

N Sriram, S Kalayarasan, G Sudhandiran - Pulmonary pharmacology & …, 2009 - Elsevier
The mechanism involved in the enhancement of antioxidant activities and resolved
inflammation after epigallocatechin-3-gallate (EGCG) treatment during bleomycin-induced …

Pharmacotherapy of acute lung injury and acute respiratory distress syndrome

K Raghavendran, GS Pryhuber… - Current medicinal …, 2008 - ingentaconnect.com
Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are
characterized by rapid-onset respiratory failure following a variety of direct and indirect …

Cellular and molecular events leading to renal tubulointerstitial fibrosis

MS Razzaque, T Taguchi - Medical Electron Microscopy, 2002 - Springer
Connective tissue remodeling of the extracellular matrix (ECM) is an essential and dynamic
process associated with both physiological responses, such as wound healing, and …

Effects of the fibroblast activation protein inhibitor, PT100, in a murine model of pulmonary fibrosis

C Egger, C Cannet, C Gérard, T Suply, I Ksiazek… - European journal of …, 2017 - Elsevier
Bleomycin (BLM) induced lung injury is detectable in C57BL/6 mice using magnetic
resonance imaging (MRI). We investigated the effects of the fibroblast activation protein …

Idiopathic pulmonary fibrosis: current understanding of the pathogenesis and the status of treatment

N Khalil, R O'Connor - Cmaj, 2004 - Can Med Assoc
IDIOPATHIC PULMONARY FIBROSIS (IPF) is a progressive and lethal pulmonary fibrotic
lung disease. The diagnostic histological changes are called usual interstitial pneumonia …

Functional role and species-specific contribution of arginases in pulmonary fibrosis

K Kitowska, D Zakrzewicz… - … of Physiology-Lung …, 2008 - journals.physiology.org
Lung fibrosis is characterized by increased deposition of ECM, especially collagens, and
enhanced proliferation of fibroblasts. l-arginine is a key precursor of nitric oxide, asymmetric …

Stromal cell‐derived factor 1 (SDF‐1) and its receptor CXCR 4 in the formation of postburn hypertrophic scar (HTS)

J Ding, K Hori, R Zhang, Y Marcoux… - Wound Repair and …, 2011 - Wiley Online Library
Recent data support the involvement of stromal cell‐derived factor 1 (SDF‐1) in the homing
of bone marrow‐derived stem cells to wound sites during skeletal, myocardial, vascular …