Conditioned media from cell lines: A complementary model to clinical specimens for the discovery of disease‐specific biomarkers

P Dowling, M Clynes - Proteomics, 2011 - Wiley Online Library
In the strictest sense, the cell secretome (conditioned media) refers to the collection of
proteins that contain a signal peptide and are processed via the endoplasmic reticulum and …

[HTML][HTML] Diagnostic utility of galectin-3 in thyroid cancer

CG Chiu, SS Strugnell, OL Griffith, SJM Jones… - The American journal of …, 2010 - Elsevier
Galectin-3 (Gal-3), which has received significant recent attention for its utility as a
diagnostic marker for thyroid cancer, represents the most well-studied molecular candidate …

Quantification of 782 plasma peptides by multiplexed targeted proteomics

A Lesur, F Bernardin, E Koncina… - Journal of Proteome …, 2023 - ACS Publications
Blood analysis is one of the foundations of clinical diagnostics. In recent years, the analysis
of proteins in blood samples by mass spectrometry has taken a jump forward in terms of …

Follicular thyroid neoplasms can be classified as low-and high-risk according to HBME-1 and Galectin-3 expression on liquid-based fine-needle cytology

G Fadda, ED Rossi, M Raffaelli… - European journal of …, 2011 - academic.oup.com
Abstract Design Fine-needle aspiration biopsy (FNAB) is the most reliable diagnostic tool in
the diagnosis of thyroid nodules. A cytologic diagnosis of follicular neoplasm with atypical …

Glioma pathophysiology: insights emerging from proteomics

RF Deighton, R McGregor, J Kemp… - Brain …, 2010 - Wiley Online Library
Proteomics is increasingly employed in both neurological and oncological research to
provide insight into the molecular basis of disease but rarely has a coherent, novel …

Galectins as cancer biomarkers

V Balan, P Nangia-Makker, A Raz - Cancers, 2010 - mdpi.com
Galectins are a group of proteins that bind β-galactosides through evolutionarily conserved
sequence elements of the carbohydrate recognition domain (CRD). Proteins similar to …

Machine learning reveals salivary glycopatterns as potential biomarkers for the diagnosis and prognosis of papillary thyroid cancer

X Ren, J Shu, J Wang, Y Guo, Y Zhang, L Yue… - International Journal of …, 2022 - Elsevier
The diagnosis of thyroid cancer, especially papillary thyroid cancer (PTC), is increasing
rapidly worldwide. In this study, we aimed to study the glycosylation of salivary proteins …

Preoperative diagnosis of thyroid nodules using the Bethesda System for Reporting Thyroid Cytopathology: a comprehensive review and meta-analysis

BS Sheffield, H Masoudi, B Walker… - Expert review of …, 2014 - Taylor & Francis
Fine-needle aspiration biopsy (FNAB) is the test of choice for the evaluation of nodules,
arriving at a cancer diagnosis, and guiding surgical management. This review and meta …

Application of metabolomics in thyroid cancer research

A Wojakowska, M Chekan, P Widlak… - International journal …, 2015 - Wiley Online Library
Thyroid cancer is the most common endocrine malignancy with four major types
distinguished on the basis of histopathological features: papillary, follicular, medullary, and …

Redox and label-free array detection of protein markers in human serum

X Luo, Q Xu, T James, JJ Davis - Analytical chemistry, 2014 - ACS Publications
A substantial outstanding challenge in diagnostics and disease monitoring is an ability to
rapidly and conveniently assay for protein biomarkers within complex biological media …