Caffeine is the most widely consumed behaviorally active substance in the world. Almost all
caffeine comes from dietary sources (beverages and food), most of it from coffee and tea …

Four adenosine receptors have been cloned and characterized from several mammalian
species. The receptors are named adenosine A1, A2A, A2B, and A3. The A2A and A2B …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Adenosine exerts two parallel modulatory roles in the CNS, acting as a homeostatic
modulator and also as a neuromodulator at the synaptic level. We will present evidence to …

It is well known that the nucleoside adenosine exerts a modulatory influence in the central
nervous system by activating G protein coupled receptors. Adenosine A2A receptors, the …

The A2A adenosine receptor (A2A‐AR) transcript and radioligand binding sites have a
distinct distribution in rat brain, restricted primarily to the striatum, nucleus accumbens and …

Major depressive disorder is one of the most common and debilitating psychiatric disorders.
Some of the motivational symptoms of depression, such anergia (lack of self-reported …

The classification of receptors for adenosine, ATP and ADP (collectively called
purinoceptors) has seen a number of developments in the past three years. The important …

The distribution, molecular structure and role of adenosine A2 receptors in the nervous
system, is reviewed. The adenosine A2a receptor subtype, identified in the nervous system …

In the pursuit of improved treatments for Parkinson's disease (PD), the adenosine A2A
receptor has emerged as an attractive nondopaminergic target. Based on the compelling …