Several promising strategies based on combining or cycling different antibiotics have been
proposed to increase efficacy and counteract resistance evolution, but we still lack a deep …

Many systems on our planet shift abruptly and irreversibly from the desired state to an
undesired state when forced across a “tipping point”. Some examples are mass extinctions …

Microbes from the three domains of life, Bacteria, Archaea, and Eukarya, share the need to
sense and respond to changes in the external and internal concentrations of protons. When …

Bacterial populations are highly adaptive. They can respond to stress and survive in shifting
environments. How the behaviours of individual bacteria vary during stress, however, is …

Bacteria can be adapted to adverse and detrimental conditions that induce general and
specific responses to DNA damage as well as acid, heat, cold, starvation, oxidative …

The Earth is home to environments characterized by low pH, including the gastrointestinal
tract of vertebrates and large areas of acidic soil. Most bacteria are neutralophiles, but can …

Genetically identical bacterial cells commonly display different phenotypes. This phenotypic
heterogeneity is well known for stress responses, where it is often explained as bet hedging …

Background The discovery and use of antibiotics have produced tremendous benefits for
human society, however, with the large-scale use of antibiotics in medicine, animal …

The emergence of antibiotic resistance mechanisms among bacterial pathogens increases
the demand for novel treatment strategies. Lately, the contribution of non-coding RNAs to …

Cellular responses to environmental changes are often highly heterogeneous and exhibit
seemingly random dynamics. The astonishing insight of chaos theory is that such …