Kratom (Mitragyna speciosa Korth., Rubiaceae) is a plant native to Southeast Asia, where it
has been used for centuries as a mild stimulant and as medicine for various ailments. More …

In ligand bias different agonist drugs are thought to produce distinct signaling outputs when
activating the same receptor. If these signaling outputs mediate therapeutic versus adverse …

Psychoactive natural products play an integral role in the modern world. The tremendous
structural complexity displayed by such molecules confers diverse biological activities of …

Mitragyna speciosa is a medicinal plant with a reputation for treating pains, diabetes as well
as increasing energy and sexual desires. However, there is no scientific evidence to validate …

Background Mitragyna speciosa, referred to as “kratom”, is increasingly used in the United
States for self-treating pain, psychiatric, and substance use disorder symptoms. It is used by …

The leaves of Mitragyna speciosa (kratom), a plant native to Southeast Asia, are increasingly
used as a pain reliever and for attenuation of opioid withdrawal symptoms. Using the tools of …

Mitragynine and 7-hydroxymitragynine (7OH) are the major alkaloids mediating the
biological actions of the psychoactive plant kratom. To investigate the structure–activity …

Kratom, a plant that produces opioid-like effects, has gained popularity in the US for self-
treating symptoms of chronic pain, mood disorders, and substance-use disorders (SUDs) …

Oral formulations prepared from the leaves of the kratom (Mitragyna speciosa) plant are
increasingly used for their opioid‐like effects to self‐manage opioid withdrawal and pain …

Increasing use of the botanical kratom to self-manage opioid withdrawal and pain has led to
increased kratom-linked overdose deaths. Despite these serious safety concerns, rigorous …