JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin
Erythropoietin(EPO) regulates the proliferation and differentiation of erythroid cells through
interaction with its receptor (EPOR). Although EPOR is a member of the cytokine receptor …
interaction with its receptor (EPOR). Although EPOR is a member of the cytokine receptor …
[HTML][HTML] IRF3 mediates a TLR3/TLR4-specific antiviral gene program
SE Doyle, SA Vaidya, R O'Connell, H Dadgostar… - Immunity, 2002 - cell.com
We have identified a subset of genes that is specifically induced by stimulation of TLR3 or
TLR4 but not by TLR2 or TLR9. Further gene expression analyses established that …
TLR4 but not by TLR2 or TLR9. Further gene expression analyses established that …
[HTML][HTML] Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
X Chen, U Vinkemeier, Y Zhao, D Jeruzalmi, JE Darnell… - Cell, 1998 - cell.com
The crystal structure of the DNA complex of a STAT-1 homodimer has been determined at
2.9 Å resolution. STAT-1 utilizes a DNA-binding domain with an immunoglobulin fold, similar …
2.9 Å resolution. STAT-1 utilizes a DNA-binding domain with an immunoglobulin fold, similar …
Inhibition of Stat1-mediated gene activation by PIAS1
B Liu, J Liao, X Rao, SA Kushner… - Proceedings of the …, 1998 - National Acad Sciences
STAT (signal transducer and activator of transcription) proteins are latent cytoplasmic
transcription factors that become activated by tyrosine phosphorylation in response to …
transcription factors that become activated by tyrosine phosphorylation in response to …
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
K Shuai, CM Horvath, LHT Huang, SA Qureshi… - Cell, 1994 - cell.com
Stat91 (a 91 kd protein that acts as a slgnal transducer and activator of transcription) is
inactive in the cytoplasm of untreated cells but is activated by phosphorylation on tyrosine in …
inactive in the cytoplasm of untreated cells but is activated by phosphorylation on tyrosine in …
Cell Growth Arrest and Induction of Cyclin-Dependent Kinase Inhibitor p21WAF1/CIP1 Mediated by STAT1
YE Chin, M Kitagawa, WCS Su, ZH You, Y Iwamoto… - Science, 1996 - science.org
Signal transducers and activators of transcription (STAT) proteins can be conditionally
activated in response to epidermal growth factor (EGF) and interferon (IFN)-γ. STAT …
activated in response to epidermal growth factor (EGF) and interferon (IFN)-γ. STAT …
[PDF][PDF] Biology of progesterone action during pregnancy recognition and maintenance of pregnancy
TE Spencer, FW Bazer - Front Biosci, 2002 - article.imrpress.com
[Frontiers in Bioscience 7, d1879-1898, September 1, 2002] 1879 BIOLOGY OF
PROGESTERONE ACTION DURING PREGNANCY RECOGNITION AND Page 1 [Frontiers in …
PROGESTERONE ACTION DURING PREGNANCY RECOGNITION AND Page 1 [Frontiers in …
The regulation of transcription by phosphorylation
Primary gene induction or repression in eukaryotes does not require de novo protein
synthesis, suggesting the involvement of posttranslational modifications. Since many …
synthesis, suggesting the involvement of posttranslational modifications. Since many …
Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis
YE Chin, M Kitagawa, K Kuida… - Molecular and cellular …, 1997 - Am Soc Microbiol
Protein tyrosine kinases activate the STAT (signal transducer and activator of transcription)
signaling pathway, which can play essential roles in cell differentiation, cell cycle control …
signaling pathway, which can play essential roles in cell differentiation, cell cycle control …
[HTML][HTML] The JAK-STAT pathway: from structural biology to cytokine engineering
Y Lv, J Qi, JJ Babon, L Cao, G Fan, J Lang… - … and Targeted Therapy, 2024 - nature.com
The Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway
serves as a paradigm for signal transduction from the extracellular environment to the …
serves as a paradigm for signal transduction from the extracellular environment to the …