Background: Randomized, controlled trials have shown that nurse-led disease management
for patients with heart failure can reduce hospitalizations. Less is known about the cost …

Background. The incidence of reported pertussis among adolescents, adults, and young
infants has increased sharply over the past decade. Combined acellular pertussis vaccines …

Promoting human health and safety by reducing exposures to risks and harms through
regulatory interventions is among the most important responsibilities of the government …

Our objective was to assess the 5-year cost effectiveness of bronchodilator therapy with
tiotropium, salmeterol or ipratropium for chronic obstructive pulmonary disease (COPD) from …

Awareness of errors in health care has skyrocketed in recent years, and huge resources
have been mobilised to measure and reduce the harm. This is a good thing, and long …

CONTEXT: Although there are many nonsurgical therapies available for the treatment of
pain associated with osteoarthritis (OA), their long-term use and safety have not been …

OBJECTIVE: Depression is common, costly, treatable, and a major influence on quality of
life. Cost-utility analysis combines costs with quantity and quality of life into a metric that is …

While the past decade has seen the development of multiple new interventions to diagnose
and treat cancer, as well as to improve the quality of life for cancer patients, many of these …

BACKGROUND Hepatitis B virus (HBV) patients with cirrhosis are at risk for developing
costly, morbid, or mortal events, and therefore need highly effective therapies. Lamivudine is …

Objective Viscosupplementation with hylan GF 20 has recently become registered for
treatment of patients with osteoarthritis (OA) of the knee in most parts of the world. The cost …