The miR-200 family of microRNAs: fine tuners of epithelial-mesenchymal transition and circulating cancer biomarkers

I Cavallari, F Ciccarese, E Sharova, L Urso… - Cancers, 2021 - mdpi.com
Simple Summary MicroRNAs (miRNAs) are small RNA molecules that regulate gene
expression by blocking translation or inducing degradation of specific gene transcripts. The …

[HTML][HTML] Triple-negative breast cancer: current treatment strategies and factors of negative prognosis

A Baranova, M Krasnoselskyi, V Starikov… - Journal of medicine …, 2022 - ncbi.nlm.nih.gov
Breast cancer is the most common cancer in women and the most common cause of death
in working-age women. According to the results of immunohistochemical studies, 10–20% of …

Non-coding RNAs as liquid biopsy biomarkers in cancer

S Toden, A Goel - British journal of cancer, 2022 - nature.com
Although non-coding RNAs have long been considered as non-functional “junk” RNAs,
accumulating evidence in the past decade indicates that they play a critical role in …

Genetic heterogeneity, tumor microenvironment and immunotherapy in triple-negative breast cancer

E Kudelova, M Smolar, V Holubekova… - International Journal of …, 2022 - mdpi.com
Heterogeneity of triple-negative breast cancer is well known at clinical, histopathological,
and molecular levels. Genomic instability and greater mutation rates, which may result in the …

MicroRNAs in extracellular vesicles: sorting mechanisms, diagnostic value, isolation, and detection technology

D Xu, K Di, B Fan, J Wu, X Gu, Y Sun… - … in Bioengineering and …, 2022 - frontiersin.org
MicroRNAs (miRNAs) are a class of short, single-stranded, noncoding RNAs, with a length
of about 18–22 nucleotides. Extracellular vesicles (EVs) are derived from cells and play a …

New molecular mechanisms and clinical impact of circRNAs in human cancer

G Fontemaggi, C Turco, G Esposito, S Di Agostino - Cancers, 2021 - mdpi.com
Simple Summary Circular RNAs (circRNAs) belong to a new class of non-coding RNAs
implicated in cellular physiological functions but also in the evolution of various human …

Notch signaling in acute inflammation and sepsis

N Gallenstein, L Tichy, MA Weigand… - International Journal of …, 2023 - mdpi.com
Notch signaling, a highly conserved pathway in mammals, is crucial for differentiation and
homeostasis of immune cells. Besides, this pathway is also directly involved in the …

Circular RNAs as potential biomarkers in breast cancer

FDE De Palma, F Salvatore, JG Pol, G Kroemer… - Biomedicines, 2022 - mdpi.com
Due to the high heterogeneity and initially asymptomatic nature of breast cancer (BC), the
management of this disease depends on imaging together with immunohistochemical and …

Long non-coding RNAs as new players in bladder cancer: Lessons from pre-clinical and clinical studies

S Mirzaei, MDA Paskeh, F Hashemi, A Zabolian… - Life Sciences, 2022 - Elsevier
The clinical management of bladder cancer (BC) has become an increasing challenge due
to high incidence rate of BC, malignant behavior of cancer cells and drug resistance. The …

Unraveling immune-related lncRNAs in breast cancer molecular subtypes

C Mathias, JCD Muzzi, BB Antunes, DF Gradia… - Frontiers in …, 2021 - frontiersin.org
Breast cancer (BRCA) is the most leading cause of cancer worldwide. It is a heterogeneous
disease with at least five molecular subtypes including luminal A, luminal B, basal-like …