Nitrogen heterocycles are essential parts of the chemical machinery of life and often reveal
intriguing structures. They are not only widespread in terrestrial habitats but can also …

Marine polysaccharides (MPs) are exceptional bioactive materials that possess unique
biochemical mechanisms and pharmacological stability, making them ideal for various …

Abstract The enzyme glutaminase-1 (GLS-1) has shown a clear and coherent implication in
the progression and exacerbation of different aggressive tumors such as glioblastoma …

Only a mere fraction of the huge variety of human pathogenic viruses can be targeted by the
currently available spectrum of antiviral drugs. The severe acute respiratory syndrome …

Mitochondria are the primary source of energy production in cells, supporting the metabolic
demand of tissue. The dysfunctional mitochondria are implicated in various diseases …

The worldwide overall 5‐year survival rate of esophageal squamous cell carcinoma (ESCC)
patients is less than 20%, and novel therapeutic strategies for these patients are urgently …

Liver cancer is the third most common cause of cancer-related deaths in the world and has
become an urgent problem for global public health. Bioactive substances are widely used …

The title of this essay is as much a question as it is a statement. The discovery of the β-
lactam antibiotics—including penicillins, cephalosporins, and carbapenems—as largely (if …

Derived from bountiful marine organisms (predominantly algae, fauna, and
microorganisms), marine polysaccharides and marine oligosaccharides are intricate …

Increasing disease-related proteins have been identified as novel therapeutic targets.
Macrocycles are emerging as potential solutions, bridging the gap between conventional …