Akt is a serine/threonine kinase and it participates in the key role of the PI3K signaling
pathway. The Akt can be activated by a wide range of growth signals and the biochemical …

Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

Solute carrier family 39 member 10 (SLC39A10) belongs to a subfamily of zinc transporters
and plays a key role in B-cell development. Previous studies have reported that its …

Prostate cancer is a leading cause of death worldwide and new estimates revealed prostate
cancer as the leading cause of death in men in 2021. Therefore, new strategies are pertinent …

Melanoma is the most lethal type of skin cancer, originating from the malignant
transformation of melanocyte. While the development of targeted therapy and …

Abstract Background Sirtuin-7 (SIRT7) is associated with the maintenance of tumorigenesis.
However, its functional roles and oncogenic mechanisms in prostate cancer (PCa) are …

Sirtuins (SIRTs), enzymes from the family of NAD+-dependent histone deacetylases, play an
important role in the functioning of the body at the cellular level and participate in many …

Optimal therapeutic strategies for liver cancer patients remain challenging due to the high
recurrence rate after surgical resection and chemotherapy resistance. Emerging evidence …

Histone deacetylases (HDACs) are enzymes that play a role in chromatin remodeling and
epigenetics. They belong to a specific category of enzymes that eliminate the acetyl part of …

Abstract Small nucleolar RNA SNORD50A and SNORD50B (SNORD50A/B) has been
reported to be recurrently deleted and function as a putative tumor suppressor in different …