CD8 T cells play crucial roles in immune surveillance and defense against infections and
cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire …

Cancer vaccines exhibit specificity, effectiveness, and safety as an alternative
immunotherapeutic strategy to struggle against malignant diseases, especially with the rapid …

Radiation therapy (RT) activates an in situ vaccine effect when combined with immune
checkpoint blockade (ICB), yet this effect may be limited because RT does not fully optimize …

Hypoxia at the solid tumor site is generally related to the unrestricted proliferation and
metabolism of cancerous cells, which can cause tumor metastasis and aggravate tumor …

Recent advances in neoantigen research have accelerated the development of tumor
immunotherapies, including adoptive cell therapies (ACTs), cancer vaccines and antibody …

Importance High levels of ERBB2 (formerly HER2)–specific type 1 T cells in the peripheral
blood are associated with favorable clinical outcomes after trastuzumab therapy; however …

As cancer immunotherapy using immune checkpoint inhibitors (ICIs) is rapidly evolving in
clinical practice, it is necessary to identify biomarkers that will allow the selection of cancer …

T cells dynamically rewire their metabolism during an immune response. We applied single-
cell RNA sequencing to CD8+ T cells activated and differentiated in vitro in physiological …

As the prominent feature of the development and progression of head and neck squamous
cell carcinoma (HNSCC) is immunosuppression, therapeutic strategies to restore antitumor …

Immunotherapy continues to be in the spotlight of oncology therapy research in the past few
years and has been proven to be a promising option to modulate one's innate and adaptive …