Changes in mRNA stability and translation are critical control points in the regulation of gene
expression, particularly genes encoding growth factors, inflammatory mediators, and proto …

Post‐transcriptional control of gene expression is aberrant in cancer cells. Sustained
stabilization and enhanced translation of specific mRNAs are features of tumor cells. AU …

We measured half-lives of 21,248 mRNA 3′ isoforms in yeast by rapidly depleting RNA
polymerase II from the nucleus and performing direct RNA sequencing throughout the decay …

Abstract Adenylate-uridylate (AU)-rich elements (AREs) are sequence instability elements
that are known to be located in the 3′ untranslated regions (UTR) in thousands of human …

A majority of messenger RNA precursors (pre-mRNAs) in the higher eukaryotes undergo
alternative splicing to generate more than one mature product. By targeting the open …

Most of the mammalian genome consists of nucleotide sequences not coding for proteins.
Exons of genes make up only 3% of the human genome, while the significance of most other …

The activities of RNA‐binding proteins are perturbed in several pathological conditions,
including cancer. These proteins include tristetraprolin (TTP, ZFP36) and HuR (ELAVL1) …

Cytokines and growth factors regulate cell proliferation, differentiation, migration and
apoptosis, and play important roles in coordinating growth signal responses during …

In this work, we assessed whether SERPINE1 expression could be under the influence of
microRNAs (miRNAs) predicted to bind the SERPINE1 3′ UTR region. We specifically …

The function of cytoplasmic PABPs [poly (A)-binding proteins] in promoting mRNA
translation has been intensively studied. However, PABPs also have less clearly defined …