Gene expression in Kinetoplastids
CE Clayton - Current opinion in microbiology, 2016 - Elsevier
Highlights•Kinetoplastids do not control transcription of individual protein-coding
genes.•mRNAs are made from polycistronic precursors by trans splicing and …
genes.•mRNAs are made from polycistronic precursors by trans splicing and …
Trypanosoma Cruzi Genome: Organization, Multi-Gene Families, Transcription, and Biological Implications
A Herreros-Cabello, F Callejas-Hernández, N Gironès… - Genes, 2020 - mdpi.com
Chagas disease caused by the parasite Trypanosoma cruzi affects millions of people.
Although its first genome dates from 2005, its complexity hindered a complete assembly and …
Although its first genome dates from 2005, its complexity hindered a complete assembly and …
Transcriptome Remodeling in Trypanosoma cruzi and Human Cells during Intracellular Infection
Y Li, S Shah-Simpson, K Okrah, AT Belew… - PLoS …, 2016 - journals.plos.org
Intracellular colonization and persistent infection by the kinetoplastid protozoan parasite,
Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global …
Trypanosoma cruzi, underlie the pathogenesis of human Chagas disease. To obtain global …
Ribosome profiling reveals translation control as a key mechanism generating differential gene expression in Trypanosoma cruzi
Background Due to the absence of transcription initiation regulation of protein coding genes
transcribed by RNA polymerase II, posttranscriptional regulation is responsible for the …
transcribed by RNA polymerase II, posttranscriptional regulation is responsible for the …
Gene expression regulatory networks in Trypanosoma brucei: insights into the role of the mRNA‐binding proteome
Control of gene expression at the post‐transcriptional level is essential in all organisms, and
RNA‐binding proteins play critical roles from mRNA synthesis to decay. To fully understand …
RNA‐binding proteins play critical roles from mRNA synthesis to decay. To fully understand …
Codon usage bias controls mRNA and protein abundance in trypanosomatids
Protein abundance differs from a few to millions of copies per cell. Trypanosoma brucei
presents an excellent model for studies on codon bias and differential gene expression …
presents an excellent model for studies on codon bias and differential gene expression …
Transcriptome‐wide analysis of trypanosome mRNA decay reveals complex degradation kinetics and suggests a role for co‐transcriptional degradation in …
A frican trypanosomes are an excellent system for quantitative modelling of post‐
transcriptional mRNA control. Transcription is constitutive and polycistronic; individual …
transcriptional mRNA control. Transcription is constitutive and polycistronic; individual …
Expression of the RNA-binding protein RBP10 promotes the bloodstream-form differentiation state in Trypanosoma brucei
In nearly all eukaryotes, cellular differentiation is governed by changes in transcription, and
stabilized by chromatin and DNA modification. Gene expression control in the pathogen …
stabilized by chromatin and DNA modification. Gene expression control in the pathogen …
The emerging role of RNA‐binding proteins in the life cycle of Trypanosoma brucei
NG Kolev, E Ullu, C Tschudi - Cellular microbiology, 2014 - Wiley Online Library
One of the key questions in understanding the biology of an organism is how to correlate
cellular fate and function with gene expression patterns. This is particularly relevant for …
cellular fate and function with gene expression patterns. This is particularly relevant for …
African trypanosomes
African trypanosomes cause human African trypanosomiasis and animal African
trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa. Although most …
trypanosomiasis. They are transmitted by tsetse flies in sub-Saharan Africa. Although most …