Metastatic colorectal cancer is a prevalent disease for which novel targeted therapies and
biologically based combinations are under development. Cytotoxic chemotherapy doublets …

The nonsteroidal anti‐inflammatory agent aspirin is widely used for preventing and treating
cardiovascular and cerebrovascular diseases. In addition, epidemiologic evidences reveal …

Colorectal cancer (CRC) is one of the most lethal malignancies worldwide and CRC therapy
remains unsatisfactory. In recent decades, nitric oxide (NO)—a free-radical gas—plus its …

Abstract Annexin A1 (ANXA1), a mediator of the anti-inflammatory action of glucocorticoids,
is important in cancer development and progression, whereas NF-κB regulates multiple …

Anticancer agents act, at least in part, by inducing reactive oxygen and nitrogen species
(RONS). We examined the redox effect on SW480 and HT-29 colon cancer cells of four …

Cancer prevention sometimes referred to as tertiary prevention or chemoprevention makes
use of specific xenobiotics or drugs to prevent, delay, or retard the development of cancer …

Abstract Development of drugs from natural products has been undergoing a gradual
evoluation. Many plant derived compounds have excellent therapeutic potential against …

It is becoming increasingly apparent that the tumor microenvironment plays an important
role in the progression of cancer. The microenvironment may promote tumor cell survival …

Nuclear factor kappa B (NF-κB)-mediated transcription is an important mediator for cellular
responses to DNA damage. Genotoxic agents trigger a'nuclear-to-cytoplasmic'NF-κB …

Introduction 3. Metabolism and physiological effects of polyamines and nitric oxide on
normal and cancerous colonic epithelial cells 3.1. Metabolism of L-arginine in the polyamine …