Converging evidence continues to point towards Tau aggregation and pathology formation
as central events in the pathogenesis of Alzheimer's disease and other Tauopathies …

Tau is well established as a microtubule-associated protein in neurons. However, under
pathological conditions, aberrant assembly of tau into insoluble aggregates is accompanied …

Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …

The past decades have witnessed great progress in nanoparticle (NP)‐based brain‐
targeting drug delivery systems, while their therapeutic potentials are yet to be fully exploited …

Among the long list of age-related complications, Alzheimer's disease (AD) has the most
dreadful impact on the quality of life due to its devastating effects on memory and cognitive …

Neurodegenerative diseases, including Alzheimer, Parkinson, Huntington, and amyotrophic
lateral sclerosis, are a prominent class of neurological diseases currently without a cure …

Autophagy is an important cellular self-digestion and recycling pathway that helps in
maintaining cellular homeostasis. Dysregulation at various steps of the autophagic and …

Abstract Nuclear Factor-Erythroid Factor 2 (Nrf2) is an important transcription factor that
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …

Tau is a microtubule-associated protein with versatile functions in the dynamic assembly of
the neuronal cytoskeleton. Four-repeat (4R-) tauopathies are a group of neurodegenerative …

A growing list of Alzheimer's disease (AD) genetic risk factors is being identified, but the
contribution of each variant to disease mechanism remains largely unknown. We have …