Cell-based therapeutics are an emerging modality with the potential to treat many currently
intractable diseases through uniquely powerful modes of action. Despite notable recent …

Transplantation is often the last resort for end-stage organ failures, eg, kidney, liver, heart,
lung, and pancreas. The shortage of donor organs is the main limiting factor for successful …

Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad
prospects for human therapeutic model development and livestock breeding. Despite …

Porcine cells devoid of three major carbohydrate xenoantigens, αGal, Neu5GC, and SDa
(TKO) exhibit markedly reduced binding of human natural antibodies. Therefore, it is …

Transplantable Tissue—Immune and Genome Engineering Dramatic advancements in the
use of synthetic and mechanical devices to replace tissues have been made, but restoring …

For many patients with terminal/advanced cardiac failure, heart transplantation is the most
effective, durable treatment option, and offers the best prospects for a high quality of life. The …

Porcine kidney xenotransplantation is accelerating towards clinical translation. However,
despite the demonstrated ability of porcine kidneys to remove metabolic waste products …

Histone modifications are critical epigenetic indicators of chromatin state associated with
gene expression. Although the reprogramming patterns of H3K4me3 and H3K27me3 have …

Swine is biologically one of the most relevant large animal models for biomedical research.
With its use as food animal that can be exploited as a free cell and tissue source for research …

Facile gene editing has accelerated progress in pig to non-human-primate (NHP) renal
xenotransplantation, however, outcomes are considered inferior to NHP-allotransplantation …