Significance: Although most researches into the changes in skin with age focus on the
unwelcome aesthetic aspects of the aging skin, skin deterioration with age is more than a …

The epidermis is a stratified epithelium that functions as a barrier protecting the organism
from dehydration, mechanical trauma, and microbial insults. This barrier function is …

Fatty acid uptake and altered metabolism constitute hallmarks of metastasis,, yet evidence of
the underlying biology, as well as whether all dietary fatty acids are prometastatic, is lacking …

During normal development, the epidermis and hair follicle are distinct lineage
compartments maintained by independent stem cell populations. Both epidermal and …

As life expectancy in industrialized countries increases, appropriate care of elderly skin
looms as a dermatologic priority. Skin aging is a complex, multifactorial process whose …

The primary function of the skin is that of a physical barrier against the environment and
diverse pathogens; therefore, its integrity is essential for survival. Skin regeneration depends …

As life expectancy in the US increases—and with it the proportion of the aged in the
population—appropriate care of elderly skin becomes a medical concern of increasing …

The bulge region of adult murine hair follicles harbors epidermal stem cells with multipotent
capacity; however, the restricted contributions of these cells under homeostatic conditions …

Homeostatic epidermal tissue renewal is the result of the combined activity of rare but potent
stem cells, and a large pool of short-lived progenitor cells termed transit amplifying cells …

An adequate permeability barrier function of the mammalian epidermis is guaranteed by the
characteristic architecture of the stratum corneum. This uppermost layer consists of a highly …