All plasmids that spread by conjugative transfer encode a relaxase. That includes plasmids
that encode the type IV secretion machinery necessary to mediate cell to cell transfer, as …

Replication initiator proteins (Reps) from the HUH-endonuclease superfamily process
specific single-stranded DNA (ssDNA) sequences to initiate rolling circle/hairpin replication …

Synthetic DNA-protein conjugates have found widespread applications in diagnostics and
therapeutics, prompting a growing interest in developing chemical biology methodologies …

Replication-initiating HUH endonucleases (Reps) are sequence-specific nucleases that
cleave and rejoin single-stranded DNA (ssDNA) during rolling-circle replication. These …

Klebsiella pneumoniae is a primary culprit of antibiotic-resistant nosocomial infections
worldwide, and infections caused by NDM-producing strains are a major threat due to …

DNA replication is essential to all living organisms as it ensures the fidelity of genetic
material for the next generation of dividing cells. One of the simplest replication initiation …

Conjugation is a key mechanism for horizontal gene transfer and plays an important role in
bacterial evolution, especially with respect to antibiotic resistance. However, little is known …

Horizontal gene transfer via plasmid conjugation enables antimicrobial resistance (AMR) to
spread among bacteria and is a major health concern. The range of potential transfer hosts …

Indole works as an interspecies signal molecule to regulate multiple physiological activities,
like antibiotic resistance, acid resistance, and virulence. However, the effect of indole on …

ABSTRACT NAH7 and pWW0 from gammaproteobacterial Pseudomonas putida strains are
IncP-9 conjugative plasmids that carry the genes for degradation of naphthalene and …