There is a growing interest in using natural medicines to treat stroke as the leading cause of
disability worldwide. Especially plant-derived natural medicines have multiple beneficial …

Background Shikonin is one of the major phytochemical components of Lithospermum
erythrorhizon (Purple Cromwell), which is a type of medicinal herb broadly utilized in …

Background Colorectal cancer (CRC) is a malignant affliction that burdens people globally.
Overactivated Hedgehog signal is highly implicated in CRC pathogenesis. Phytochemical …

Abstract Andrographis paniculata (Burm. f.) Wall. ex Nees, a renowned herb medicine in
China, is broadly utilized in traditional Chinese medicine (TCM) for the treatment of cold and …

Oridonin, as a natural terpenoids found in traditional Chinese herbal medicine Isodon
rubescens (Hemsl.) H. Hara, is widely present in numerous Chinese medicine preparations …

Exploring multi-targeting chemotherapeutants with advantages over single-targeting agents
and drug combinations is of great significance in drug discovery. Herein, we employed …

Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease of colon and rectum
with unknown etiology, and the lesions are mainly confined to the mucosa and submucosa …

β-Carboline alkaloids are a remarkable family of natural and synthetic indole-containing
heterocyclic compounds and they are widely distributed in nature. Recently, these alkaloids …

As an important part of complementary and alternative medicine, traditional Chinese
medicine (TCM) has been applied to treat a host of diseases for centuries. Over the years …

Chronic pain is one of the most prevalent health problems. The establishment of chronic
pain is complex. Current medication for chronic pain mainly dependent on anticonvulsants …