In the liver, the progressive accumulation of connective tissue, a complex and dynamic
process termed fibrosis, represents a very frequent event following a repeated or chronic …

Various chronic disease processes are characterized by progressive accumulation of
connective tissue undergoing fibrotic degeneration. Evidence of oxidative reactions is often …

Nonalcoholic fatty liver disease (NAFLD) is a global health-care problem with limited
therapeutic options. To obtain a cellular resolution of pathogenesis, 82,168 single-cell …

Immune dysregulations in alcoholic liver diseases are still unclear, especially regarding
alcoholic hepatitis inflammatory burst. Interleukin‐17 (IL‐17) is known to enhance neutrophil …

Abstract Effects of antioxidants, resveratrol, quercetin, and N-acetylcysteine (NAC) on the
functions of cultured rat hepatic stellate cells and Kupffer cells were studied. These …

Chronic liver damage is a widespread pathology characterized by a progressive evolution
from steatosis to chronic hepatitis, fibrosis, cirrhosis, and hepatocellular carcinoma. As the …

As a model for the analysis of the fibrosuppressive role of estradiol, hepatic fibrosis was
induced in male and female rats by the administration of a single dose of …

Liver fibrosis is a chronic liver disease that will further develop to cirrhosis if severe damage
continues to form. A potential treatment for liver fibrosis is to inhibit activated hepatic stellate …

Activation of hepatic stellate cells (HSCs) is the key step in liver fibrogenesis. Increased
transforming growth factor β (TGF-β) expression and extracellular matrix production in …

Background & Aims: Hepatic stellate cells (HSCs) are considered the principal matrix-
producing cells of the damaged liver. However, other cell types of the fibroblast lineage that …