The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities

Z Huang, AH Rose, PR Hoffmann - Antioxidants & redox signaling, 2012 - liebertpub.com
Abstract Dietary selenium (] Se), mainly through its incorporation into selenoproteins, plays
an important role in inflammation and immunity. Adequate levels of Se are important for …

The influence of selenium on immune responses

PR Hoffmann, MJ Berry - Molecular nutrition & food research, 2008 - Wiley Online Library
Selenium (Se) is a potent nutritional antioxidant that carries out biological effects through its
incorporation into selenoproteins. Given the crucial roles that selenoproteins play in …

Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases

DB Kell - BMC medical genomics, 2009 - Springer
Background The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular'reactive oxygen species'(ROSs) can exhibit a …

Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's …

DB Kell - Archives of toxicology, 2010 - Springer
Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

Oxidative stress indexes for diagnosis of health or disease in humans

MA Sánchez-Rodríguez… - Oxidative medicine and …, 2019 - Wiley Online Library
Oxidative stress (OS) is the imbalance between oxidant and antioxidant molecules, in favor
of oxidants, that causes aging and disease. Many studies have been published that …

Diet and asthma: nutrition implications from prevention to treatment

K Allan, G Devereux - Journal of the American Dietetic Association, 2011 - Elsevier
Asthma is characterized by lung airway inflammation initiated and perpetuated by an
inappropriate immune response, increased airway responsiveness, and variable airflow …

Zinc metabolism in airway epithelium and airway inflammation: basic mechanisms and clinical targets. A review

PD Zalewski, AQ Truong-Tran, D Grosser… - Pharmacology & …, 2005 - Elsevier
In addition to basic housekeeping roles in metalloenzymes and transcription factors, dietary
zinc (Zn) is an important immunoregulatory agent, growth cofactor, and cytoprotectant with …

Selenium and selenoproteins in prostanoid metabolism and immunity

F Qian, S Misra, KS Prabhu - Critical reviews in biochemistry and …, 2019 - Taylor & Francis
Selenium (Se) is an essential trace element that functions in the form of the 21st amino acid,
selenocysteine (Sec) in a defined set of proteins. Se deficiency is associated with …

The role of zinc in the pathogenesis of lung disease

X Liu, MK Ali, K Dua, R Xu - Nutrients, 2022 - mdpi.com
Lung diseases, such as asthma, chronic obstructive pulmonary diseases (COPD), and cystic
fibrosis (CF), are among the leading causes of mortality and morbidity globally. They …

Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma

MK Ali, RY Kim, AC Brown, JR Mayall… - European …, 2020 - Eur Respiratory Soc
Accumulating evidence highlights links between iron regulation and respiratory disease.
Here, we assessed the relationship between iron levels and regulatory responses in clinical …