Epilepsy is a common and serious neurologic disease with a strong genetic component.
Genetic studies have identified an increasing collection of disease-causing genes. The …

Two-photon microscopy (TPM) offers improved deep visualization of the target specimen
with reduced phototoxicity, autofluorescence, and minimal light scattering. In combination …

The CORUM database has been providing comprehensive reference information about
experimentally characterized, mammalian protein complexes and their associated biological …

Potassium (K+) efflux across the plasma membrane is thought to be an essential mechanism
for ATP-induced NLRP3 inflammasome activation, yet the identity of the efflux channel has …

Various artificial transmembrane transporters, designed to function through mobile carrier or
channel mechanisms, have been developed in the past decade. With the aid of structural …

Covering: 1925 to July 2023 Among the sesquiterpenoids with rich structural diversity and
potential bioactivities, lindenane sesquiterpenoids (LSs) possess a characteristic cis, trans …

Fluorescent compounds based on synthetic small molecules are powerful tools to visualize
biological events in living cells and organisms. Ever since the discovery of organic …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

The pharmacologic profile of retigabine [RTG (international nonproprietary name);
ezogabine, EZG (US adopted name)], is different from all currently approved antiepileptic …

This review addresses novel concepts of histamine H1‐receptor function and attempts to
relate them to the anti‐inflammatory effects of H1‐antihistamines. Furthermore, the …