Inflammasomes are critical sentinels of the innate immune system that respond to threats to
the host through recognition of distinct molecules, known as pathogen-or damage …

Mitochondria have recently emerged as key drivers of inflammation associated with cell
death. Many of the pro-inflammatory pathways activated during cell death occur upon …

Gasdermin D (GSDMD)-activated inflammatory cell death (pyroptosis) causes mitochondrial
damage, but its underlying mechanism and functional consequences are largely unknown …

Double-stranded RNA (dsRNA) is associated with most viral infections—it either constitutes
the viral genome (in the case of dsRNA viruses) or is generated in host cells during viral …

The regulated disruption of the plasma membrane, which can promote cell death, cytokine
secretion or both is central to organismal health. The protein gasdermin D (GSDMD) is a key …

Pyroptosis is the process of inflammatory cell death. The primary function of pyroptosis is to
induce strong inflammatory responses that defend the host against microbe infection …

Low back pain (LBP) is a major musculoskeletal disorder and the socioeconomic problem
with a high prevalence that mainly involves intervertebral disc (IVD) degeneration …

Canonically, gasdermin D (GSDMD) cleavage by caspase-1 through inflammasome
signaling triggers immune cell pyroptosis (ICP) as a host defense against pathogen …

According to the endosymbiotic theory, most of the DNA of the original bacterial
endosymbiont has been lost or transferred to the nucleus, leaving a much smaller (∼ 16 kb …

The number of old people is rising worldwide, and advancing age is a major risk factor for
atherosclerotic cardiovascular disease. However, the mechanisms underlying this …