Tumor blood vessels are a key target for cancer therapeutic management. Tumor cells
secrete high levels of pro-angiogenic factors which contribute to the creation of an abnormal …

Formation of distant metastases is by far the most common cause of cancer-related deaths.
The process of metastasis formation is complex, and within this complex process the …

Statins are inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR), which
is a rate-limiting enzyme in the mevalonate pathway. The pleiotropic effects of statins may be …

Decades of research have elucidated the critical role of Akt isoforms in cancer as pro-
tumorigenic and metastatic regulators through their specific effects on the cancer cells, tumor …

Introduction Glioblastoma multiforme (GBM) is the most common brain malignancy in adults,
and currently available GBM treatments present several unique challenges. It is known that …

Prostate cancer (PCa), one of the most commonly diagnosed cancers worldwide, still
presents important unmet clinical needs concerning treatment. In the last years, the …

Prostate cancer (PCa) is the most frequently diagnosed cancer and the third highest cause
of cancer-related deaths in men in the US The development of chemotherapeutic agents that …

Background Cancer research, in general, is focused on targeting tumour cells to limit tumour
growth. These studies, however, do not account for the specific effects of chemotherapy on …

Arsenic trioxide (ATO) and statins have been demonstrated to have anti‐neoplastic
properties; however, the data regarding their combination therapy is limited. Thus, we aimed …

Prostate cancer (PCa) is one of the most common male-specific cancers worldwide, with
high morbidity and mortality rates associated with advanced disease stages. The current …