Bone grafts have been predominated used to treat bone defects, delayed union or non-
union, and spinal fusion in orthopaedic clinically for a period of time, despite the emergency …

Currently, the clinical treatment of critical bone defects attributed to various causes remains
a great challenge, and repairing these defects with synthetic bone substitutes is the most …

Zinc is a micronutrient of key importance for human health. An increasing number of studies
indicate that zinc plays a significant role in bone tissue's normal development and …

Bioactive glasses caused a revolution in healthcare and paved the way for modern
biomaterial-driven regenerative medicine. The first 45S5 glass composition, invented by …

Bone defects are commonly caused by severe trauma, malignant tumors, or congenital
diseases and remain among the toughest clinical problems faced by orthopedic surgeons …

Zinc is an essential mineral that is required for normal skeletal growth and bone
homeostasis. Furthermore, zinc appears to be able to promote bone regeneration. However …

Bone tissue engineering utilizes three critical elements–cells, scaffolds, and bioactive factors–
to recapitulate the bone tissue microenvironment, inducing the formation of new bone …

Implant-related infections caused by drug-resistant bacteria remain a major challenge faced
by orthopedic surgeons. Furthermore, ideal prevention and treatment methods are lacking in …

Additive manufacturing has received attention for the fabrication of medical implants that
have customized and complicated structures. Biodegradable Zn metals are revolutionary …

In recent years, Zn-based materials provide a new option as biodegradable metals for
orthopedic applications. To improve the low strength and brittle nature of pure Zn, small …