[HTML][HTML] Kinase inhibition in autoimmunity and inflammation
AA Zarrin, K Bao, P Lupardus, D Vucic - Nature Reviews Drug …, 2021 - nature.com
Despite recent advances in the treatment of autoimmune and inflammatory diseases, unmet
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …
medical needs in some areas still exist. One of the main therapeutic approaches to alleviate …
Personalized medicine for patients with COPD: where are we?
FME Franssen, P Alter, N Bar… - … journal of chronic …, 2019 - Taylor & Francis
Chronic airflow limitation is the common denominator of patients with chronic obstructive
pulmonary disease (COPD). However, it is not possible to predict morbidity and mortality of …
pulmonary disease (COPD). However, it is not possible to predict morbidity and mortality of …
Prospects for COPD treatment
MG Matera, M Cazzola, C Page - Current Opinion in Pharmacology, 2021 - Elsevier
The management of chronic obstructive pulmonary disease (COPD) is fundamentally still
heavily dependent on the use of bronchodilators and corticosteroids. Therefore, there is a …
heavily dependent on the use of bronchodilators and corticosteroids. Therefore, there is a …
Novel anti-inflammatory approaches to COPD
M Cazzola, NA Hanania, CP Page… - International journal of …, 2023 - Taylor & Francis
Airway inflammation, driven by different types of inflammatory cells and mediators, plays a
fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and …
fundamental role in COPD and its progression. Neutrophils, eosinophils, macrophages, and …
[HTML][HTML] p38 MAPK signaling in chronic obstructive pulmonary disease pathogenesis and inhibitor therapeutics
Background Chronic obstructive pulmonary disease (COPD) is characterized by persistent
respiratory symptoms and airflow limitation due to airway and/or alveolar remodeling …
respiratory symptoms and airflow limitation due to airway and/or alveolar remodeling …
Role of p38 mitogen-activated protein kinase in asthma and COPD: pathogenic aspects and potential targeted therapies
Among the various members of the mitogen-activated protein kinase (MAPK) family, p38
MAPK subgroup is the most involved in airway and lung inflammation underlying asthma …
MAPK subgroup is the most involved in airway and lung inflammation underlying asthma …
LncRNA‐MAP3K4 regulates vascular inflammation through the p38 MAPK signaling pathway and cis‐modulation of MAP3K4
Chronic vascular inflammation plays a key role in the pathogenesis of atherosclerosis. Long
non‐coding RNAs (lncRNAs) have emerged as essential inflammation regulators. We …
non‐coding RNAs (lncRNAs) have emerged as essential inflammation regulators. We …
Nanoparticle-exposure-triggered virus reactivation induces lung emphysema in mice
L Han, V Haefner, Y Yu, B Han, H Ren, M Irmler… - ACS …, 2023 - ACS Publications
Nanoparticles (NPs) released from engineered materials or combustion processes as well
as persistent herpesvirus infection are omnipresent and are associated with chronic lung …
as persistent herpesvirus infection are omnipresent and are associated with chronic lung …
Role of p38-mitogen-activated protein kinase in COPD: pathobiological implications and therapeutic perspectives
C Pelaia, A Vatrella, A Sciacqua… - Expert Review of …, 2020 - Taylor & Francis
Introduction: The p38 serine-threonine kinases are members of the large family of mitogen-
activated protein kinases (MAPK). In particular, p38 MAPK subgroup includes four isoforms …
activated protein kinases (MAPK). In particular, p38 MAPK subgroup includes four isoforms …
[HTML][HTML] P38 MAPK and glucocorticoid receptor crosstalk in bronchial epithelial cells
Abstract p38 MAPK inhibition may have additive and synergistic anti-inflammatory effects
when used with corticosteroids. We investigated crosstalk between p38 MAPK inhibitors and …
when used with corticosteroids. We investigated crosstalk between p38 MAPK inhibitors and …