Differentiated cells have long been considered fixed in their identity. However, about 20
years ago, the first direct conversion of glial cells into neurons in vitro opened the field of" …

Gradient scaffolds are isotropic/anisotropic three-dimensional structures with gradual
transitions in geometry, density, porosity, stiffness, etc., that mimic the biological extracellular …

Injectable biomimetic hydrogels have great potential for use in regenerative medicine as
cellular delivery vectors. However, they can suffer from issues relating to hypoxia, including …

The development of neural interfaces with superior biocompatibility and improved tissue
integration is vital for treating and restoring neurological functions in the nervous system. A …

The ability to repair or promote regeneration within the adult human brain has been
envisioned for decades. Until recently, such efforts mainly involved delivery of growth factors …

Decreasing the activation of pathology-activated microglia is crucial to prevent chronic
inflammation and tissue scarring. In this study, we used a stab wound injury model in …

The development of techniques to create and use multiphase microstructured hydrogels
(granular hydrogels or microgels) has enabled the generation of cultures with more …

Astrocytes are particularly promising candidates for reprogramming into neurons, as they
maintain some of the original patterning information from their radial glial ancestors …

Astrocyte-to-neuron conversion is a promising avenue for neuronal replacement therapy.
Neurons are particularly dependent on mitochondrial function, but how well mitochondria …

Neural stem cells (NSCs) hold great promise for neural repair in cases of CNS injury and
neurodegeneration; however, conventional cell-based transplant methods face the …