Telomerase reverse transcriptase (TERT/hTERT) serves as the pivotal catalytic subunit of
telomerase, a crucial enzyme responsible for telomere maintenance and human genome …

Epigenetic alterations, including aberrant DNA methylation, are now recognized as bone
fide hallmarks of cancer, which can contribute to cancer initiation, progression, therapy …

The telomerase reverse transcriptase (TERT) is overexpressed and associated with poor
prognosis in papillary thyroid cancer (PTC), the most common subtype of thyroid cancer. The …

Abstract Background Cysteine dioxygenase 1 (CDO1) is frequently methylated, and its
expression is decreased in many human cancers including breast cancer (BC). However …

Telomerase is associated with cellular aging, and its presence limits cellular lifespan.
Telomerase by preventing telomere shortening can extend the number of cell divisions for …

Background DNA hypermethylation and hotspot mutations were frequently observed in the
upstream and core promoter of telomerase reverse transcriptase (TERT), respectively, and …

Background Activation of dominant oncogenes by small or structural genomic alterations is a
common driver mechanism in many cancers. Silencing of such dominantly activated …

Some benign and malignant breast tumours are similar in pathological morphology, which
are difficult to be distinguished in clinical diagnosis. In this study, we intended to explore …

Strong epigenetic pan-cancer biomarkers are required to meet several current, urgent
clinical needs and to further improve the present chemotherapeutic standard. We have …

Purpose Risk stratification based on somatic mutations in TERT promoter and BRAF/RAS
has been well established for papillary thyroid cancer (PTC), and there is emerging …