The term epigenetics refers to stable patterns of gene expression that are seen during
differentiation or X chromosome inactivation and are not dependent on dynamic changes in …

Colorectal cancer (CRC) is a multifactorial disease resulting from lifestyle, genetic, and
environmental factors. There are hereditary and non-hereditary CRC types; however, the …

Colorectal cancer arises as a consequence of the accumulation of genetic alterations (gene
mutations, gene amplification, and so on) and epigenetic alterations (aberrant DNA …

Summary Cyclin-dependent kinase 9 (CDK9) promotes transcriptional elongation through
RNAPII pause release. We now report that CDK9 is also essential for maintaining gene …

Since the first publication on Somatic Mutation Theory of Aging (Szilárd, 1959), a great
volume of knowledge in the field has been accumulated. Here we attempted to organize the …

The past few years have seen an explosion of interest in the epigenetics of cancer. This has
been a consequence of both the exciting coalescence of the chromatin and DNA …

Although obesity, reduced physical activity, and aging increase susceptibility to type 2
diabetes, many people exposed to these risk factors do not develop the disease. Recent …

Cytosine methylation is required for mammalian development and is often perturbed in
human cancer. To determine how this epigenetic modification is distributed in the genomes …

It is becoming clear that epigenetic changes are involved in human disease as well as
during normal development. A unifying theme of disease epigenetics is defects in …

Background: DNA methylation is a form of epigenetic modification that has been shown to
play a significant role in gene regulation. In cancer, DNA methylation plays an important role …