Cutaneous lupus erythematosus (CLE) is an autoimmune disease that can present as an
isolated skin disease or as a manifestation within the spectrum of systemic lupus …

The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in
development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT …

Bone growth and the maintenance of bone structure are controlled by multiple endocrine
and paracrine factors, including cytokines expressed locally within the bone …

FIG 2. A, The median Treact in relation to the challenge dose. B, The median Swheal in
relation to the challenge dose. Both graphs (box plots) display the distribution of the data as …

Heterozygous mutations in JAK1 which result in JAK-STAT hyperactivity have been
implicated in an autosomal dominant disorder that features multi-organ immune …

Background Cutaneous lupus erythematosus (CLE) is an interferon (IFN)-driven
autoimmune skin disease characterized by an extensive cytotoxic lesional inflammation with …

Background Systemic lupus erythematosus (SLE) comprise a diverse range of clinical
manifestations. To date, more than 30 single gene causes of lupus/lupus like syndromes in …

The Janus kinase (JAK) signal transducer and activator of transcription (STAT) signaling
pathway serves as an important downstream mediator for a variety of cytokines, hormones …

Highlights•Chronic itch is a defining feature of atopic dermatitis (AD).•New studies reveal
how cytokines can directly modulate sensory neurons to influence atopic itch.•Disrupting …

Cutaneous lupus erythematosus (CLE) is an interferon (IFN)-driven autoimmune disease
that may be limited to the skin or can be associated with systemic lupus erythematosus …