Breast cancer is the second leading cause of death for women worldwide. The
heterogeneity of this disease presents a big challenge in its therapeutic management …

Recent rapid biotechnological breakthroughs have led to the identification of complex and
unique molecular features that drive malignancies. Precision medicine has exploited next …

Abstract Cyclin-dependent kinase (CDK) 4/6 inhibition in combination with endocrine
therapy is the standard-of-care treatment for patients with advanced-stage hormone receptor …

Immune-checkpoint inhibitors (ICIs) have transformed patient care in oncology but are
associated with a unique spectrum of organ-specific inflammatory toxicities known as …

Breast cancer is the most commonly occurring cancer in women. There were over two-
million new cases in world in 2018. It is the second leading cause of death from cancer in …

Deregulation of cell cycle, via cyclin D/CDK/pRb pathway, is frequently observed in breast
cancer lending support to the development of drugs targeting the cell cycle control …

Precision medicine has exploited next-generation sequencing (NGS) and gene/immune-
targeted drug deployment to transform the outlook for several lethal cancers. For instance …

Inhibition of cyclin-dependent kinases (CDKs) has become an effective therapeutic strategy
for treating various diseases, especially cancer. Over almost three decades, although great …

Background We aimed to evaluate overall survival in US patients with amyotrophic lateral
sclerosis (ALS) treated with intravenous (IV) edaravone compared with those not treated …

The use of digital twins (DTs) has proliferated across various fields and industries, with a
recent surge in the healthcare sector. The concept of digital twin for health (DT4H) holds …