Biological utility of fluorinated compounds: from materials design to molecular imaging, therapeutics and environmental remediation
The applications of fluorinated molecules in bioengineering and nanotechnology are
expanding rapidly with the controlled introduction of fluorine being broadly studied due to …
expanding rapidly with the controlled introduction of fluorine being broadly studied due to …
Chemical aspects of human and environmental overload with fluorine
Over the last 100–120 years, due to the ever-increasing importance of fluorine-containing
compounds in modern technology and daily life, the explosive development of the …
compounds in modern technology and daily life, the explosive development of the …
Contribution of organofluorine compounds to pharmaceuticals
M Inoue, Y Sumii, N Shibata - ACS omega, 2020 - ACS Publications
Inspired by the success of fluorinated corticosteroids in the 1950s and fluoroquinolones in
the 1980s, fluorine-containing pharmaceuticals, which are also known as fluoro …
the 1980s, fluorine-containing pharmaceuticals, which are also known as fluoro …
Fluorine-containing drugs approved by the FDA in 2021
J He, Z Li, G Dhawan, W Zhang, AE Sorochinsky… - Chinese Chemical …, 2023 - Elsevier
Nine new fluorine-containing drugs have been approved by the US Food and Drug
Administration (FDA) in 2021, which are presented in this review article. These small …
Administration (FDA) in 2021, which are presented in this review article. These small …
Fluorinated pyrazoles: From synthesis to applications
PK Mykhailiuk - Chemical Reviews, 2020 - ACS Publications
Fluorinated pyrazoles play an important role in medicinal chemistry, drug discovery,
agrochemistry, coordination chemistry, and organometallic chemistry. Since the early 1990s …
agrochemistry, coordination chemistry, and organometallic chemistry. Since the early 1990s …
Strategies for Nucleophilic C(sp3)–(Radio)Fluorination
This Perspective surveys the progress and current limitations of nucleophilic fluorination
methodologies. Despite the long and rich history of C (sp3)–F bond construction in chemical …
methodologies. Despite the long and rich history of C (sp3)–F bond construction in chemical …
Next generation organofluorine containing blockbuster drugs
The role of organo-fluorine compounds in modern health, food and energy related industries
is widely-appreciated. The unique properties that fluorine imparts to organic molecules …
is widely-appreciated. The unique properties that fluorine imparts to organic molecules …
New halogen-containing drugs approved by FDA in 2021: An overview on their syntheses and pharmaceutical use
This review describes the recent Food and Drug Administration (FDA)-approved drugs (in
the year 2021) containing at least one halogen atom (covalently bound). The structures …
the year 2021) containing at least one halogen atom (covalently bound). The structures …
Where does the fluorine come from? A review on the challenges associated with the synthesis of organofluorine compounds
S Caron - Organic Process Research & Development, 2020 - ACS Publications
Fluorinated organic molecules are increasingly being prepared for a variety of applications,
including pharmaceutical products. However, the supply chain to access the necessary raw …
including pharmaceutical products. However, the supply chain to access the necessary raw …
Highlights on US FDA-approved fluorinated drugs over the past five years (2018–2022)
The objective of this review is to provide an update on the fluorine-containing drugs
approved by US Food and Drug Administration in the span of past five years (2018–2022) …
approved by US Food and Drug Administration in the span of past five years (2018–2022) …