The current tuberculosis (TB) predicament poses numerous challenges and therefore every
incremental scientific work and all positive socio-political engagements, are steps taken in …

The nitro group is considered to be a versatile and unique functional group in medicinal
chemistry. Despite a long history of use in therapeutics, the nitro group has toxicity issues …

Sažetak Determination of metabolic profiles of new chemical entities is a key step in the
process of drug discovery, since it influences pharmacokinetic characteristics of therapeutic …

Pollutants from industry and chemical laboratories have harmful effects on human health
and the environment. Concerns about this problem have led to the development of more …

Bedaquiline is a new drug of the diarylquinoline class that has proven to be clinically
effective against drug-resistant tuberculosis, but has a cardiac liability (prolongation of the …

The increasing drug resistance of M ycobacterium tuberculosis to the currently used drugs
and HIV coinfection has caused alarm in the international scientific community …

Tuberculosis remains a leading cause of death resulting from an infectious agent, and the
spread of multi-and extensively drug-resistant strains of Mycobacterium tuberculosis poses a …

Nitroimidazole represents one of the most essential and unique scaffolds in drug discovery
since its discovery in the 1950s. It was K. Maeda in Japan who reported in 1953 the first …

Delamanid, bedaquiline, and pretomanid have been recently added in the anti-tuberculosis
(anti-TB) treatment regimens and have emerged as potential solutions for combating drug …

Replacing the naphthalene C-unit of the anti-tuberculosis drug bedaquiline with a range of
bicyclic heterocycles of widely differing lipophilicity gave analogs with a 4.5-fold range in …