Critical features of human addiction are increasingly being incorporated into complementary
animal models, including escalation of drug intake, punished drug seeking and taking …

Cannabis is the most commonly used substance of abuse in the United States after alcohol
and tobacco. With a recent increase in the rates of cannabis use disorder (CUD) and a …

Alcohol-dependent patients commonly show impairments in executive functions that
facilitate craving and can lead to relapse. However, the molecular mechanisms leading to …

Central nervous system neurons communicate via fast synaptic transmission mediated by
ligand-gated ion channel (LGIC) receptors and slower neuromodulation mediated by G …

Drug addiction is responsible for millions of deaths per year around the world. Still, its
management as a chronic disease is shadowed by misconceptions from the general public …

Alcohol addiction is a chronic relapsing brain disease characterized by an impaired ability to
stop or control alcohol use despite adverse consequences. A main challenge of addiction …

Metabotropic glutamate (mGlu) receptors, a family of G-protein-coupled receptors, have
been identified as novel therapeutic targets based on extensive research supporting their …

Abstract In 1986, Gawin and Kleber reported a progressive increase in cue-induced drug
craving in individuals with cocaine use disorders during prolonged abstinence. After years of …

There is a high co-occurrence of risky substance use among adults with traumatic brain
injury (TBI), although it is unknown if the neurologic sequelae of TBI can promote this …

Orphan G-protein-coupled receptors (oGPCRs) possess untapped potential for drug
discovery. In the brain, oGPCRs are generally expressed at low abundance and their …