The locus coeruleus (LC)-noradrenergic system is the main source of noradrenaline in the
central nervous system and is involved intensively in modulating pain and stress-related …

Chronic pain is a significant global socioeconomic burden with limited long-term treatment
options. The intractable nature of chronic pain stems from two primary factors: the …

Trigeminal neuralgia is the most common neuropathic pain involving the craniofacial region.
Due to the complex pathophysiology, it is therapeutically difficult to manage. Noradrenaline …

Neuropathic pain is a debilitating chronic condition provoked by a lesion in the nervous
system and it induces functional alterations to the noradrenergic locus coeruleus (LC) …

Background Dynamic changes in neuronal activity and in noradrenergic locus coeruleus
(LC) projections have been proposed during the transition from acute to chronic pain. Thus …

Comorbid pain and mood disorders can produce circuit-specific maladaptive plasticity;
however, several translational issues require addressing to maximise future therapeutic …

Diabetic neuropathy is the loss of sensory function beginning distally in the lower
extremities, which is also characterized by pain and substantial morbidity. Furthermore, the …

The locus coeruleus (LC) plays a paradoxical role in chronic pain. Although largely known
as a potent source of endogenous analgesia, increasing evidence suggests injury can …

Selective manipulation of neural circuits using optogenetics and chemogenetics holds great
translational potential but requires genetic access to neurons. Here, we demonstrate a …

Neuropathic pain is a debilitating chronic condition provoked by a lesion in the nervous
system and it induces functional alterations to the noradrenergic locus coeruleus (LC) …