[HTML][HTML] Extracellular Vesicles as Drug Delivery Systems in Organ Transplantation: The Next Frontier

HVM Spiers, LKJ Stadler, H Smith, V Kosmoliaptsis - Pharmaceutics, 2023 - mdpi.com
Extracellular vesicles are lipid bilayer-delimited nanoparticles excreted into the extracellular
space by all cells. They carry a cargo rich in proteins, lipids and DNA, as well as a full …

Liver disease and cell therapy: advances made and remaining challenges

S Khan, S Mahgoub, N Fallatah, PF Lalor… - Stem Cells, 2023 - academic.oup.com
The limited availability of organs for liver transplantation, the ultimate curative treatment for
end stage liver disease, has resulted in a growing and unmet need for alternative therapies …

Novel approaches to characterize individual drug metabolism and advance precision medicine

KD Jackson, B Achour, J Lee, RM Geffert… - Drug metabolism and …, 2023 - ASPET
Interindividual variability in drug metabolism can significantly affect drug concentrations in
the body and subsequent drug response. Understanding an individual's drug metabolism …

Exosomes in chronic liver disease

PB Mohan, S Rajpurohit, B Musunuri, G Bhat… - Clinica Chimica …, 2023 - Elsevier
Chronic liver disease (CLD) is the major cause of mortality and morbidity, particularly in
developing countries. Although there has been a significant advancement in the …

[HTML][HTML] The emerging role of extracellular vesicles and autophagy machinery in NASH—Future horizons in NASH management

EM Trifylli, AG Kriebardis, E Koustas… - International Journal of …, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is considered the most frequent chronic hepatic
disease in the general population, while it is the first cause of liver transplantation in the US …

A narrative review of the role of exosomes and caveolin-1 in liver diseases and cancer

X Jiang, S Wu, C Hu - International Immunopharmacology, 2023 - Elsevier
Abstract Exosomes are nanoscale (40–100 nm) vesicles secreted by different types of cells
and have attracted extensive interest in recent years because of their unique role in disease …

[HTML][HTML] Comprehensive strategy for identifying extracellular vesicle surface proteins as biomarkers for non-alcoholic fatty liver disease

NA Garcia, M Mellergaard, H Gonzalez-King… - International Journal of …, 2023 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a liver disorder that has become a global health
concern due to its increasing prevalence. There is a need for reliable biomarkers to aid in …

[HTML][HTML] Plasma Pattern of Extracellular Vesicles Isolated from Hepatitis C Virus Patients and Their Effects on Human Vascular Endothelial Cells

E Grossini, C Smirne, S Venkatesan, S Tonello… - International Journal of …, 2023 - mdpi.com
Hepatitis C virus (HCV) patients are at increased risk of cardiovascular disease (CVD). In
this study, we aimed to evaluate the role of extracellular vesicles (EVs) as pathogenic factors …

Survey of organ‐derived small extracellular vesicles and particles (sEVPs) to identify selective protein markers in mouse serum

K Abdelmohsen, AB Herman, AE Carr… - Journal of …, 2023 - Wiley Online Library
Extracellular vesicles and particles (EVPs) are secreted by organs across the body into
different circulatory systems, including the bloodstream, and reflect pathophysiologic …

[HTML][HTML] Extracellular Vesicles as Delivery Vehicles for Non-Coding RNAs: Potential Biomarkers for Chronic Liver Diseases

A Ferro, G Saccu, S Mattivi, A Gaido… - Biomolecules, 2024 - mdpi.com
In recent years, EVs have emerged as promising vehicles for coding and non-coding RNAs
(ncRNAs), which have demonstrated remarkable potential as biomarkers for various …