In recent years, there has been an increase in the prevalence of hyperuricemia, and the
latter has attracted attention as an adult lifestyle-associated disease, together with …

Heart failure (HF) is a syndrome characterized by high mortality, frequent hospitalization,
reduced quality of life, and a complex therapeutic regimen. Knowledge about HF is …

A transthoracic echocardiogram is recommended in patients with suspected heart failure, to
improve diagnostic accuracy, and in patients with a new diagnosis of heart failure, to assess …

Activation of the renin–angiotensin–aldosterone system (RAAS) results in vasoconstriction,
muscular (vascular and cardiac) hypertrophy and fibrosis. Established arterial stiffness and …

Low blood pressure is common in patients with heart failure and reduced ejection fraction
(HFrEF). While spontaneous hypotension predicts risk in HFrEF, there is only limited …

Importance Despite evidence that guideline-directed medical therapy (GDMT) improves
outcomes in patients with heart failure (HF) and reduced ejection fraction, many patients are …

The development of the neurohormonal model of heart failure (HF) has underpinned a
tremendous growth in basic and clinical investigations into HF physiology and clinical …

Background Physicians' adherence to guideline‐recommended therapy is associated with
short‐term clinical outcomes in heart failure (HF) with reduced ejection fraction (HFrEF) …

Background: Patients with left ventricular (LV) systolic dysfunction after myocardial infarction
are at a high risk of developing heart failure. The addition of neprilysin inhibition to renin …

Sarcopenia, a critical loss of muscle mass and function because of the physiological process
of aging, contributes to disability and mortality in older adults. It increases the incidence of …