Despite worsening heart failure (HF) being extremely common, expensive, and associated
with substantial risk of death, there remain no dedicated clinical practice guidelines for the …

Hyperkalemia is a common clinical condition that can be defined as a serum potassium
concentration exceeding 5.0 mmol/L. Drug-induced hyperkalemia is the most important …

Type 2 diabetes mellitus is a risk factor for incident heart failure and increases the risk of
morbidity and mortality in patients with established disease. Secular trends in the …

It is now widely accepted that inflammation is critical in cardiovascular diseases (CVD).
Here, studies are being conducted on how cyclic GMP-AMP synthase (cGAS), a component …

Context Heart failure with preserved ejection fraction (HFPEF) may be as common and as
lethal as heart failure with reduced ejection fraction (HFREF). Three randomized trials of …

Angioedema is a rare, potentially life-threatening adverse event of renin–angiotensin system
inhibitors. The objective of the present study was to determine the risk of angioedema from …

A collective century of discoveries establishes the importance of the renin angiotensin
aldosterone system in maintaining blood pressure, fluid volume and electrolyte homeostasis …

Objectives: This study sought to determine the rate of use of target doses of foundational
guideline-directed medical therapy (GDMT) in a contemporary cohort of patients with heart …

Heart failure (HF) is a leading cause of hospitalisation, morbidity, and mortality in Canada.
There are sex-specific differences in the etiology, epidemiology, comorbidities, treatment …

Disorders of potassium homeostasis can potentiate the already elevated risk of arrhythmia in
heart failure. Heart failure patients have a high prevalence of chronic kidney disease, which …