Cycles in epilepsy

PJ Karoly, VR Rao, NM Gregg, GA Worrell… - Nature Reviews …, 2021 - nature.com
Epilepsy is among the most dynamic disorders in neurology. A canonical view holds that
seizures, the characteristic sign of epilepsy, occur at random, but, for centuries, humans …

Seizure prediction—ready for a new era

L Kuhlmann, K Lehnertz, MP Richardson… - Nature Reviews …, 2018 - nature.com
Epilepsy is a common disorder characterized by recurrent seizures. An overwhelming
majority of people with epilepsy regard the unpredictability of seizures as a major issue …

[HTML][HTML] Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy

DR Nair, KD Laxer, PB Weber, AM Murro, YD Park… - Neurology, 2020 - AAN Enterprises
Objective To prospectively evaluate safety and efficacy of brain-responsive neurostimulation
in adults with medically intractable focal onset seizures (FOS) over 9 years. Methods Adults …

Long-term brain network reorganization predicts responsive neurostimulation outcomes for focal epilepsy

AN Khambhati, A Shafi, VR Rao… - Science Translational …, 2021 - science.org
Responsive neurostimulation (RNS) devices, able to detect imminent seizures and to rapidly
deliver electrical stimulation to the brain, are effective in reducing seizures in some patients …

Forecasting seizure risk in adults with focal epilepsy: a development and validation study

T Proix, W Truccolo, MG Leguia, TK Tcheng… - The Lancet …, 2021 - thelancet.com
Background People with epilepsy are burdened with the apparent unpredictability of
seizures. In the past decade, converging evidence from studies using chronic EEG (cEEG) …

Seizure cycles in focal epilepsy

MG Leguia, RG Andrzejak, C Rummel, JM Fan… - JAMA …, 2021 - jamanetwork.com
Importance Focal epilepsy is characterized by the cyclical recurrence of seizures, but, to our
knowledge, the prevalence and patterns of seizure cycles are unknown. Objective To …

A new era in electroencephalographic monitoring? Subscalp devices for ultra–long‐term recordings

J Duun‐Henriksen, M Baud, MP Richardson… - …, 2020 - Wiley Online Library
Inaccurate subjective seizure counting poses treatment and diagnostic challenges and thus
suboptimal quality in epilepsy management. The limitations of existing hospital‐and home …

[HTML][HTML] Critical slowing down as a biomarker for seizure susceptibility

MI Maturana, C Meisel, K Dell, PJ Karoly… - Nature …, 2020 - nature.com
The human brain has the capacity to rapidly change state, and in epilepsy these state
changes can be catastrophic, resulting in loss of consciousness, injury and even death …

[HTML][HTML] Seizure diaries and forecasting with wearables: epilepsy monitoring outside the clinic

BH Brinkmann, PJ Karoly, ES Nurse… - Frontiers in …, 2021 - frontiersin.org
It is a major challenge in clinical epilepsy to diagnose and treat a disease characterized by
infrequent seizures based on patient or caregiver reports and limited duration clinical …

Machine learning and wearable devices of the future

S Beniczky, P Karoly, E Nurse, P Ryvlin, M Cook - Epilepsia, 2021 - Wiley Online Library
Abstract Machine learning (ML) is increasingly recognized as a useful tool in healthcare
applications, including epilepsy. One of the most important applications of ML in epilepsy is …