Lipids have essential biological functions in the body (eg, providing energy storage, acting
as a signaling molecule, and being a structural component of membranes); however, an …

Cholesterol homeostasis is vital for proper cellular and systemic functions. Disturbed
cholesterol balance underlies not only cardiovascular disease but also an increasing …

A common feature of cancer cells is their ability to rewire their metabolism to sustain the
production of ATP and macromolecules needed for cell growth, division and survival. In …

Hypercholesterolemia and dyslipidemia are associated with an increased risk for many
cancer types and with poor outcomes in patients with established disease. Whereas the …

Hepatocellular carcinoma (HCC) accounts for the majority of primary liver cancers and is
characterized by high recurrence and heterogeneity, yet its mechanism is not well …

Cholesterol and its metabolites (precursors and derivatives) play an important role in cancer.
In recent years, numerous studies have reported the functions of cholesterol metabolism in …

Background Proprotein convertase subtilisin/kexin type 9 (PCSK9) is the ninth member of
the proprotein convertase family that regulates lipoprotein homeostasis and altered PCSK9 …

Cholesterol plays an important role in cancer development. Both clinical and experimental
studies have found that hypercholesterolemia and a high-fat high-cholesterol diet can affect …

Obesity and elevated circulating cholesterol are risk factors for breast cancer recurrence,
while the use of statins, cholesterol biosynthesis inhibitors widely used for treating …

Background The use of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-
TKIs) brings remarkable benefits for the survival of patients with advanced NSCLC harboring …