The discovery of CD4+ T cell subset–defining master transcription factors and framing of the
Th1/Th2 paradigm ignited the CD4+ T cell field. Advances in in vivo experimental systems …

Obesity is associated with metabolic disturbances that cause tissue stress and dysfunction.
Obese individuals are at a greater risk for chronic disease and often present with clinical …

Abstract The oncometabolite (R)-2-hydroxyglutarate (R-2-HG) produced by isocitrate
dehydrogenase (IDH) mutations promotes gliomagenesis via DNA and histone methylation …

In metazoans, specific tasks are relegated to dedicated organs that are established early in
development, occupy discrete locations and typically remain fixed in size. The adult immune …

INTRODUCTION The adaptive immune system has evolved to mount different types of
responses that are matched to the type of invading pathogen. For CD4+ T cells, this is …

Tissue-resident memory CD8+ T cells (TRM) constitute a noncirculating memory T cell
subset that provides early protection against reinfection. However, how TRM arise from …

Heightened effector function and prolonged persistence, the key attributes of Th1 and Th17
cells, respectively, are key features of potent anti-tumor T cells. Here, we established ex vivo …

Group 2 innate lymphoid cells (ILC2s) in the lung are stimulated by inhaled allergens. ILC2s
do not directly recognize allergens but they are stimulated by cytokines including interleukin …

Summary Interleukin (IL)-2 and inflammation regulate effector and memory cytolytic T-
lymphocyte (CTL) generation during infection. We demonstrate a complex interplay between …

CD4+ T helper (Th) cells play central roles in immunity in health and disease. While much is
known about the effector function of Th cells in combating pathogens and promoting …