Monocytes and Macrophages in COVID-19

R Knoll, JL Schultze, J Schulte-Schrepping - Frontiers in immunology, 2021 - frontiersin.org
COVID-19 is a contagious viral disease caused by SARS-CoV-2 that led to an ongoing
pandemic with massive global health and socioeconomic consequences. The disease is …

Neutrophils in COVID-19

N Reusch, E De Domenico, L Bonaguro… - Frontiers in …, 2021 - frontiersin.org
Strong evidence has been accumulated since the beginning of the COVID-19 pandemic that
neutrophils play an important role in the pathophysiology, particularly in those with severe …

Swarm learning for decentralized and confidential clinical machine learning

S Warnat-Herresthal, H Schultze, KL Shastry… - Nature, 2021 - nature.com
Fast and reliable detection of patients with severe and heterogeneous illnesses is a major
goal of precision medicine,. Patients with leukaemia can be identified using machine …

Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection

FJ Ryan, CM Hope, MG Masavuli, MA Lynn… - BMC medicine, 2022 - Springer
Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly
infectious respiratory virus which is responsible for the coronavirus disease 2019 (COVID …

Local and systemic responses to SARS-CoV-2 infection in children and adults

M Yoshida, KB Worlock, N Huang, RGH Lindeboom… - Nature, 2022 - nature.com
It is not fully understood why COVID-19 is typically milder in children,–. Here, to examine the
differences between children and adults in their response to SARS-CoV-2 infection, we …

Cellular and transcriptional dynamics of human neutrophils at steady state and upon stress

E Montaldo, E Lusito, V Bianchessi, N Caronni… - Nature …, 2022 - nature.com
Traditionally viewed as poorly plastic, neutrophils are now recognized as functionally
diverse; however, the extent and determinants of neutrophil heterogeneity in humans remain …

RNAInter v4. 0: RNA interactome repository with redefined confidence scoring system and improved accessibility

J Kang, Q Tang, J He, L Li, N Yang, S Yu… - Nucleic acids …, 2022 - academic.oup.com
Establishing an RNA-associated interaction repository facilitates the system-level
understanding of RNA functions. However, as these interactions are distributed throughout …

Multi-omic profiling reveals widespread dysregulation of innate immunity and hematopoiesis in COVID-19

AJ Wilk, MJ Lee, B Wei, B Parks, R Pi… - Journal of Experimental …, 2021 - rupress.org
Our understanding of protective versus pathological immune responses to SARS-CoV-2, the
virus that causes coronavirus disease 2019 (COVID-19), is limited by inadequate profiling of …

[HTML][HTML] COVID-19 and the human innate immune system

JL Schultze, AC Aschenbrenner - Cell, 2021 - cell.com
The introduction of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into the
human population represents a tremendous medical and economic crisis. Innate immunity …

A guide to systems-level immunomics

L Bonaguro, J Schulte-Schrepping, T Ulas… - Nature …, 2022 - nature.com
The immune system is highly complex and distributed throughout an organism, with
hundreds to thousands of cell states existing in parallel with diverse molecular pathways …