Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …

Abstract Changes in DNA methylation in cancer have been heralded as promising targets
for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite …

Rapid progress in identifying biomarkers that are hallmarks of disease has increased
demand for high-performance detection technologies. Implementation of electrochemical …

Alcohol-related liver disease is the most prevalent type of chronic liver disease worldwide,
accounting for 30% of hepatocellular carcinoma (HCC) cases and HCC-specific deaths …

Abstract Merlin (Moesin-ezrin-radixin-like protein, also known as schwannomin) is a tumor
suppressor protein encoded by the neurofibromatosis type 2 gene NF2. Loss of function …

Over the past three decades, molecular genetic studies have revealed some critical
mutations underlying the pathogenesis of the sporadic and inherited forms of colorectal …

Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …

Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …

Background DNA methylation plays an essential role in the regulation of gene expression.
While its presence near the transcription start site of a gene has been associated with …

Increased levels of DNA fragments have frequently been found in the blood plasma of
cancer patients. Published data suggest that only a fraction of the DNA in blood plasma is …