Epigenetic alterations in the gastrointestinal tract: current and emerging use for biomarkers of cancer
WM Grady - Advances in cancer research, 2021 - Elsevier
Colorectal cancer is a leading cause of cancer related deaths worldwide. One of the
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …
hallmarks of cancer and a fundamental trait of virtually all gastrointestinal cancers is …
Analysis of DNA methylation in cancer: location revisited
A Koch, SC Joosten, Z Feng, TC de Ruijter… - Nature reviews Clinical …, 2018 - nature.com
Abstract Changes in DNA methylation in cancer have been heralded as promising targets
for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite …
for the development of powerful diagnostic, prognostic, and predictive biomarkers. Despite …
Electrochemical methods for the analysis of clinically relevant biomolecules
Rapid progress in identifying biomarkers that are hallmarks of disease has increased
demand for high-performance detection technologies. Implementation of electrochemical …
demand for high-performance detection technologies. Implementation of electrochemical …
Hepatocellular carcinoma in the setting of alcohol-related liver disease
N Ganne-Carrié, P Nahon - Journal of hepatology, 2019 - Elsevier
Alcohol-related liver disease is the most prevalent type of chronic liver disease worldwide,
accounting for 30% of hepatocellular carcinoma (HCC) cases and HCC-specific deaths …
accounting for 30% of hepatocellular carcinoma (HCC) cases and HCC-specific deaths …
Role of Merlin/NF2 inactivation in tumor biology
AM Petrilli, C Fernández-Valle - Oncogene, 2016 - nature.com
Abstract Merlin (Moesin-ezrin-radixin-like protein, also known as schwannomin) is a tumor
suppressor protein encoded by the neurofibromatosis type 2 gene NF2. Loss of function …
suppressor protein encoded by the neurofibromatosis type 2 gene NF2. Loss of function …
Molecular genetics of colorectal cancer
ER Fearon - Annual Review of Pathology: Mechanisms of …, 2011 - annualreviews.org
Over the past three decades, molecular genetic studies have revealed some critical
mutations underlying the pathogenesis of the sporadic and inherited forms of colorectal …
mutations underlying the pathogenesis of the sporadic and inherited forms of colorectal …
Genomic instability in human cancer: Molecular insights and opportunities for therapeutic attack and prevention through diet and nutrition
LR Ferguson, H Chen, AR Collins, M Connell… - Seminars in cancer …, 2015 - Elsevier
Genomic instability can initiate cancer, augment progression, and influence the overall
prognosis of the affected patient. Genomic instability arises from many different pathways …
prognosis of the affected patient. Genomic instability arises from many different pathways …
DNA methyltransferases: a novel target for prevention and therapy
Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …
agents, and the use of various therapeutic combinations, none of the available treatment …
The relationship between DNA methylation, genetic and expression inter-individual variation in untransformed human fibroblasts
Background DNA methylation plays an essential role in the regulation of gene expression.
While its presence near the transcription start site of a gene has been associated with …
While its presence near the transcription start site of a gene has been associated with …
DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells
S Jahr, H Hentze, S Englisch, D Hardt, FO Fackelmayer… - Cancer research, 2001 - AACR
Increased levels of DNA fragments have frequently been found in the blood plasma of
cancer patients. Published data suggest that only a fraction of the DNA in blood plasma is …
cancer patients. Published data suggest that only a fraction of the DNA in blood plasma is …