The promising potential of reverse vaccinology-based next-generation vaccine development over conventional vaccines against antibiotic-resistant bacteria
The clinical use of antibiotics has led to the emergence of multidrug-resistant (MDR)
bacteria, leading to the current antibiotic resistance crisis. To address this issue, next …
bacteria, leading to the current antibiotic resistance crisis. To address this issue, next …
Glycoconjugate vaccines against antimicrobial resistant pathogens
C Sorieul, M Dolce, MR Romano, J Codée… - Expert Review of …, 2023 - Taylor & Francis
Introduction Antimicrobial resistance (AMR) is responsible for the death of millions
worldwide and stands as a major threat to our healthcare systems, which are heavily reliant …
worldwide and stands as a major threat to our healthcare systems, which are heavily reliant …
[HTML][HTML] The role of vaccines in combating antimicrobial resistance (AMR) bacteria
S Alghamdi - Saudi Journal of Biological Sciences, 2021 - Elsevier
Most pathogens have developed an intrinsic capacity to thrive by developing resistance to
antimicrobial compounds utilized in treatment. Antimicrobial resistance arises when …
antimicrobial compounds utilized in treatment. Antimicrobial resistance arises when …
Efficacy of a 4-Antigen Staphylococcus aureus Vaccine in Spinal Surgery: The STaphylococcus aureus suRgical Inpatient Vaccine Efficacy (STRIVE) Randomized …
H Hassanzadeh, J Baber, E Begier… - Clinical Infectious …, 2023 - academic.oup.com
Background Staphylococcus aureus is a global pathogen that is frequently responsible for
healthcare-associated infections, including surgical site infections (SSIs). Current infection …
healthcare-associated infections, including surgical site infections (SSIs). Current infection …
A DNase-mimetic artificial enzyme for the eradication of drug-resistant bacterial biofilm infections
H Hu, X Kang, Z Shan, X Yang, W Bing, L Wu, H Ge… - Nanoscale, 2022 - pubs.rsc.org
The construction of multifunctional nano-enzymes is a feasible strategy for fighting multi-
drug resistant (MDR) bacterial biofilm-associated infections. Extracellular DNA (eDNA) is an …
drug resistant (MDR) bacterial biofilm-associated infections. Extracellular DNA (eDNA) is an …
The Candidate Antigens to Achieving an Effective Vaccine against Staphylococcus aureus
Staphylococcus aureus (S. aureus) is an opportunistic pathogen that causes various
inflammatory local infections, from those of the skin to postinfectious glomerulonephritis …
inflammatory local infections, from those of the skin to postinfectious glomerulonephritis …
Bacterial lipoprotein posttranslational modifications. New insights and opportunities for antibiotic and vaccine development
L Smithers, S Olatunji, M Caffrey - Frontiers in Microbiology, 2021 - frontiersin.org
Lipoproteins are some of the most abundant proteins in bacteria. With a lipid anchor to the
cell membrane, they function as enzymes, inhibitors, transporters, structural proteins, and as …
cell membrane, they function as enzymes, inhibitors, transporters, structural proteins, and as …
Multi-Antigen Outer Membrane Vesicle Engineering to Develop Polyvalent Vaccines: The Staphylococcus aureus Case
E König, A Gagliardi, I Riedmiller, C Andretta… - Frontiers in …, 2021 - frontiersin.org
Modification of surface antigens and differential expression of virulence factors are frequent
strategies pathogens adopt to escape the host immune system. These escape mechanisms …
strategies pathogens adopt to escape the host immune system. These escape mechanisms …
Updates on Staphylococcal Vaccines
Staphylococcus aureus, a prevalent human pathogen and a leading cause of hospital-
acquired infections, is increasingly evolving antibiotic-resistant strains, increasing mortality …
acquired infections, is increasingly evolving antibiotic-resistant strains, increasing mortality …
Development of a Staphylococcus aureus Vaccine: An Ongoing Journey
RA Proctor - Clinical Infectious Diseases, 2023 - academic.oup.com
Vaccine Efficacy (STRIVE) trial is another disappointment. However, the information
provided by Hassanzadeh et al is extremely valuable as it can instruct future clinical trials …
provided by Hassanzadeh et al is extremely valuable as it can instruct future clinical trials …