The promising potential of reverse vaccinology-based next-generation vaccine development over conventional vaccines against antibiotic-resistant bacteria

K Khalid, CL Poh - Vaccines, 2023 - mdpi.com
The clinical use of antibiotics has led to the emergence of multidrug-resistant (MDR)
bacteria, leading to the current antibiotic resistance crisis. To address this issue, next …

Glycoconjugate vaccines against antimicrobial resistant pathogens

C Sorieul, M Dolce, MR Romano, J Codée… - Expert Review of …, 2023 - Taylor & Francis
Introduction Antimicrobial resistance (AMR) is responsible for the death of millions
worldwide and stands as a major threat to our healthcare systems, which are heavily reliant …

[HTML][HTML] The role of vaccines in combating antimicrobial resistance (AMR) bacteria

S Alghamdi - Saudi Journal of Biological Sciences, 2021 - Elsevier
Most pathogens have developed an intrinsic capacity to thrive by developing resistance to
antimicrobial compounds utilized in treatment. Antimicrobial resistance arises when …

Efficacy of a 4-Antigen Staphylococcus aureus Vaccine in Spinal Surgery: The STaphylococcus aureus suRgical Inpatient Vaccine Efficacy (STRIVE) Randomized …

H Hassanzadeh, J Baber, E Begier… - Clinical Infectious …, 2023 - academic.oup.com
Background Staphylococcus aureus is a global pathogen that is frequently responsible for
healthcare-associated infections, including surgical site infections (SSIs). Current infection …

A DNase-mimetic artificial enzyme for the eradication of drug-resistant bacterial biofilm infections

H Hu, X Kang, Z Shan, X Yang, W Bing, L Wu, H Ge… - Nanoscale, 2022 - pubs.rsc.org
The construction of multifunctional nano-enzymes is a feasible strategy for fighting multi-
drug resistant (MDR) bacterial biofilm-associated infections. Extracellular DNA (eDNA) is an …

The Candidate Antigens to Achieving an Effective Vaccine against Staphylococcus aureus

HR Jahantigh, S Faezi, M Habibi, M Mahdavi… - Vaccines, 2022 - mdpi.com
Staphylococcus aureus (S. aureus) is an opportunistic pathogen that causes various
inflammatory local infections, from those of the skin to postinfectious glomerulonephritis …

Bacterial lipoprotein posttranslational modifications. New insights and opportunities for antibiotic and vaccine development

L Smithers, S Olatunji, M Caffrey - Frontiers in Microbiology, 2021 - frontiersin.org
Lipoproteins are some of the most abundant proteins in bacteria. With a lipid anchor to the
cell membrane, they function as enzymes, inhibitors, transporters, structural proteins, and as …

Multi-Antigen Outer Membrane Vesicle Engineering to Develop Polyvalent Vaccines: The Staphylococcus aureus Case

E König, A Gagliardi, I Riedmiller, C Andretta… - Frontiers in …, 2021 - frontiersin.org
Modification of surface antigens and differential expression of virulence factors are frequent
strategies pathogens adopt to escape the host immune system. These escape mechanisms …

Updates on Staphylococcal Vaccines

A Scafa-Udriste, MI Popa, GL Popa - Microbiology Research, 2023 - mdpi.com
Staphylococcus aureus, a prevalent human pathogen and a leading cause of hospital-
acquired infections, is increasingly evolving antibiotic-resistant strains, increasing mortality …

Development of a Staphylococcus aureus Vaccine: An Ongoing Journey

RA Proctor - Clinical Infectious Diseases, 2023 - academic.oup.com
Vaccine Efficacy (STRIVE) trial is another disappointment. However, the information
provided by Hassanzadeh et al is extremely valuable as it can instruct future clinical trials …